Health Category

Understanding Anti-Aging - Natural Anti-Aging Supplements, Herbs & Nutrients


 

 

About Aging & Anti Aging – Natural Anti Aging Remedies & Advice

 

Major Causes & History of Aging

Everyone experiences the aging process in a different way, but ultimately we’ll all experience profound changes in terms of how we look and how well our body functions. Despite the perhaps daunting fact that the aging process is happening to you right this very moment, the good news is that you can do something to ensure you age gracefully and stay as young and vital as possible. You can make impactful choices that will help to either slow your own aging process down or speed it up. 

Many people are quite interested in trying to slow down the process of getting older. Since aging involves a complex progression of changes, there are a wide variety of actions that people take to try and slow the aging process. People might have their own specific anti aging regimens, anti aging diets, anti aging skin creams, anti aging supplements and so forth. People also search for cognitive enhancers such as play memory games to increase brain function and improve cognitive function, take vitamins for memory and brain boosting supplements in search for the latest methods on how to improve memory and brain health to counter the effects that aging can have on your brain. What will you choose to do to age well, live healthier, longer and with a better quality of life?

 The changes caused by the aging process will significantly impact your life and how well you feel both physically and emotionally. Perhaps you’ve already witnessed these changes in your aging parents or other family members. Unfortunately, in today’s society there are a lot of people who are certainly living longer, but they’re also living with more chronic diseases than previous generations have experienced, predominantly because of unhealthy lifestyles and behaviours. Many people are growing old in years, but in some cases are living with an unnecessarily reduced and poor quality of life. These people are often living out the later years of their life in a state of disease and chronic pain, relying heavily on medications, the healthcare system and the provision of care from others. However, others are aging gracefully and managing to maintain a high level of both physical and cognitive function. Are there reasons to help explain these two contrasting scenarios? The answer to this question is yes indeed.

Not every person who is living a longer lifespan is living in a poor state of health. In fact, societies such as the Okinawa of Japan have been intensely studied to find out why so many members of their population are living incredibly well even after the age of 100, and with little or no chronic disease. Research has found that several lifestyle factors influence the longevity of this population and result in natural anti aging remedies promoting brain health, heart health and supporting a healthy cardiovascular function. The healthy anti aging diet they consume which is plentiful in colourful fruits and vegetables high in anti aging vitamin C and antioxidants, unrefined carbohydrates, lean meats and healthy fats provide anti aging nutrition vital to healthy aging. The Okinawan’s are also physically active and participate in low-intensity exercise regularly, and deeply value family and nurture positive social interaction and relationships. Living a lifestyle with low levels of stress has also contributed to the remarkable longevity of this population. 

What scientists have also learned from ongoing research on aging and how to reverse aging is that health issues and experiences that occur earlier in life greatly influence one’s health in later years. Factors such as being a healthy weight, making healthy dietary choices filled with nutritional value, being physically active and not having mental health issues or injuries can help to lower the chances that one will suffer from chronic disease conditions typically encountered with increasing age. This means that the earlier you start living in a healthy manner, the more likely it is that you’ll improve your brain power and your body’s ability to age well and reduce the chances of suffering with chronic and potentially debilitating diseases such as organ failure, dementia, heart disease or inflammatory diseases such as arthritis.

References: 

1.) Public Health Agency of Canada. Web. 2016.

2.) National Institutes of Health. Web. 2016

3.) Age Ageing. 2003 Jul;32(4):427-34. Dietary quality, lifestyle factors and healthy ageing in Europe: the SENECA study. Haveman-Nies et al. WA.

4.) Neurology. 1994 Nov;44(11):2073-80. The Canadian Study of Health and Aging: risk factors for Alzheimer's disease in Canada

5.) Health Rep. 2010 Sep;21(3):45-53. Health-promoting factors and good health among Canadians in mid- to late life. Ramage-Morin PL et al.

6.) J Aging Phys Act. 2009 Apr;17(2):223-35. Physical activity and successful aging in Canadian older adults. Baker J et al.

7.) Mech Ageing Dev. 2014 Mar-Apr;136-137:148-62. Healthy aging diets other than the Mediterranean: a focus on the Okinawan diet. Willcox DC et al.

8.)Indian J Community Med. 2009 Oct; 34(4): 273–275. Secret of Eternal Youth; Teaching from the Centenarian Hot Spots (“Blue Zones”) Badri N Mishra

 

Learn About Some Natural Anti Aging Remedies & Strategies Including Routine, Nutrition & Anti Aging Supplements to Help You Age Well

Getting adequate sleep is vital in order to stay healthy both physically and mentally as you age. Unfortunately, the process of aging causes changes in normal sleep patterns. Most adults require seven to eight hours of sleep each night, yet as a person grows older it becomes more difficult to fall and stay asleep. Experiencing sleep difficulty as you get older is often due to changes in the pattern of the sleep cycle. A person may wake up earlier and more often during the night as he or she gets older, and sleep less hours in total. Experiencing stress, anxiety and living with chronic pain can also interfere with sleep. A lack of sleep can cause confusion, cognitive changes and undermine your physical and emotional wellbeing.

Here’s what you can do to improve your sleep: 

  • Only consume a light snack before bed
  • Avoid stimulants such as caffeine for at least 3 or 4 hours before bed.
  • Avoid prolonged napping during the day 
  • Participate in light physical exercise earlier in the day
  • Avoid stimulation from artificial light sources such as computer screens and televisions before bed
  • Establish a set time for bed each night
  • Only use the bedroom for sleep and sexual activity
  • Avoid using tobacco products
  • Avoid drinking alcohol before bed
  • Ensure that any medications you are taking are not interfering with your sleep
  • After 20 minutes of not being able to sleep, get out of bed and read or do another quiet activity before returning to bed to try to fall sleep again

People may take various types of brain supplements and specific vitamins for memory. Additionally, there are many other ways to improve memory as you age. Stay mentally active by taking part in new learning activities such as playing a musical instrument, doing crossword puzzles, or playing other games considered to be brain boosters. Boost memory and practice ways on how to increase brain power and improve cognitive function simply by doing a variety of mental tasks to keep your brain active and in shape. Additionally, socializing with friends and loved ones helps prevent feelings of depression and isolation which can contribute to memory problems. As a brain boost, it’s also critical to stay well hydrated with water and consume a healthy diet that contains antioxidants from plenty of fruits, vegetables and whole grains.  

In 2010, the World Health Organization estimated that 35.6 million people lived with dementia; by 2030 this number is estimated to double and more than triple by 2050. (1) It’s important to understand that Alzheimer’s disease, a form of dementia, is not a normal part of the aging process; although getting older does increase the risk for it. Eating healthy, getting adequate physical activity and reducing the number of chronic diseases occurring in a person’s body can delay the onset of, reduce the severity of and lower the overall risk for dementia. The appropriate management of chronic diseases such as obesity, Type 2 diabetes and hypertension can help to decrease the risk of Alzheimer’s disease and other forms of dementia.

Reference: 

 1.)World Health Organization. Web. 2016.

Research studies show that exercise during your mid-life years reduces the risk for dementia. Patients with mild cognitive impairment or dementia had significantly better cognitive scores after exercising regularly over a period of six to 12 months as compared to patients who were sedentary (1). Physically in-shape seniors had a larger hippocampal area (increased gray matter), which is an indicator of brain health, than seniors who were not in-shape. Additionally, MRI’s showed that exercise improved the brain’s neural networks to contribute to enhanced brain function (1). Animal studies also confirm these results by demonstrating that exercise improves the learning abilities of animals and protects the brain’s nerve cells. Exercise also lowers the risk of cognitive decline by helping to maintain the health of the arteries and veins of the cerebrovascular system.

Older adults should participate in aerobic exercise activities that benefit cardiovascular health and take part in regular strength and flexibility training according to their ability. Working with a physician can be helpful for a person to determine the best exercise program. For example, some older adults may need to do more low impact activities such as swimming, doing the elliptical machine, or walking, if chronic joint pain is a problem; whereas others may need to focus on doing specific exercises to improve balance if falling is an issue. Take note, getting some form of healthy exercise on a regular basis will improve your overall health, mobility and dexterity.

Reference:

1)Mayo Clinic Proceedings. Physical Exercise as a Preventive or Disease-Modifying Treatment of Dementia and Brain Aging. J. Eric Ahlskog. Web. 2016

Research demonstrates that diets known to increase lifespan and slow the aging process share several common characteristics. Healthy eating patterns rich in nutrients such as those of the Mediterranean, DASH and Okinawan dietary plans have several elements in common that are all associated with a reduction in age-associated diseases such as cardiovascular disease. 

These life-extending nutritional diets include a high intake of fruits and vegetables, herbs and medicinal plants, unrefined sources of carbohydrates, legumes and lean sources of meat such as fish. These diets are also low in saturated fats and instead include more monounsaturated and polyunsaturated fats which are high in omega-3. Omega-3 fats are valuable for reducing inflammation, balancing cholesterol, supporting brain and nervous system function among other benefits. Additionally, these plant-rich diets are relatively low in calories and high in nutrients including health protective antioxidants and phytonutrients. Interestingly enough, restricting calorie intake has been shown to increase lifespan and improve health in both animal and human studies, provided appropriate nutritional needs are still met. These diets also lower oxidative stress in the body to reduce inflammation, protect cells and promote normal cell development, and are low glycemic to help one maintain a healthy weight and reduce stress on the body’s organ systems.

You likely already know that too much stress can have very damaging effects on the body. Stress can contribute to high blood pressure, stroke, heart disease, circulatory and immune problems and more. Negative behaviors such as eating poorly, smoking and abusing alcohol can also be triggered by stress and in turn cause accelerated aging. Evidence gathered from a study of nearly 3,000 working men and women confirmed that stress speeds up the biological aging process at the level of the DNA (1).

Dealing with stress in a positive way is essential for maintaining good health and cognitive function while growing older. Some of the ways to help manage stress include practicing relaxation techniques such as breathing awareness, meditation and exercising moderately on a regular basis.  Enjoying hobbies, using positive visualization techniques and sharing your concerns with a friend who can offer suggestions and help you to put things into perspective can also be helpful. Seeking professional counselling and therapy is important if you feel you cannot effectively cope with the amount of stress in your life. 

Reference: 

1.)Work-Related Exhaustion and Telomere Length: A Population-Based Study. Kirsi Ahola et al. Published: July 11, 2012. Web. 2016.

Additional References:

Canadian Mental Health Association. Web. 2016

Research indicates that antioxidant-rich foods such as blueberries, tomatoes, green leafy vegetables, nuts and certain types of fatty fish such as salmon and mackerel help to protect the skin. In general, healthy foods like those just mentioned help to enhance a person’s overall health and reduce aging. Similarly, research has also shown that taking natural anti aging supplements with concentrated antioxidants such as astaxanthin and resveratrol help to protect against sagging and wrinkling in the skin, and provide protection from the damage caused by exposure to UV radiation from the sun or other sources. Avoid foods that are highly processed or which contain unhealthy fats because these are damaging to the skin and promote aging. 

Additional References 

1.)Neil Schneiderman et al. STRESS AND HEALTH: Psychological, Behavioral, and Biological Determinants. Annu Rev Clin Psychol. Author manuscript; available in PMC 2008 Oct 16. 

2.)National Institutes of Health: Aging Changes in Sleep. Web. 2016.

3.) W. Vaughn McCall. Sleep in the Elderly: Burden, Diagnosis, and Treatment. Prim Care Companion J Clin Psychiatry. 2004; 6(1): 9–20.

4.)Colten HR, Altevogt BM, editors. Sleep Disorders and Sleep Deprivation: An Unmet Public Health Problem. Institute of Medicine (US) Committee on Sleep Medicine and Research. Washington (DC): National Academies Press (US); 2006.

5.)Mayo Clinic.Web. 2016. 

6.)Khalid Rahman. Studies on free radicals, antioxidants, and co-factors. Clin Interv Aging. 2007 Jun; 2(2): 219–236.

7.)Harvard School of Public Health: Physical activity guidelines: How much exercise do you need? Web. 2016. 

8.)Mayo Clinic. Web. 2016. 

9.)Silke K. Schagen. Discovering the link between nutrition and skin aging. Dermatoendocrinol. 2012 Jul 1; 4(3): 298–307.

10.)Suganuma K et al. Astaxanthin attenuates the UVA-induced up-regulation of matrix-metalloproteinase-1 and skin fibroblast elastase in human dermal fibroblasts. J Dermatol Sci. 2010 May;58(2):136-42.

11.)Mary Ndiaye et al. The Grape Antioxidant Resveratrol for Skin Disorders: Promise, Prospects, and Challenges. Arch Biochem Biophys. Author manuscript; available in PMC 2012 Apr 15

Natural Anti Aging Supplements, Remedies & Products

Many natural anti aging supplements serve as invaluable cognitive enhancers for those searching for supplements for hearth health, natural brain supplements to memory supplements. Some anti aging natural supplements take the spotlight for their role in helping to slow the aging process. Curcumin and resveratrol possesses remarkable antioxidant and anti-inflammatory properties to fight against aging. Co-enzyme Q10 functions as a co-enzyme in the energy-producing metabolic pathways of every cell in the body and also has powerful antioxidant effects that reduce the effects aging in the body. N-acetyl-cysteine and R lipoic acid are two of the body’s most important antioxidants because they work to keep other antioxidants active in the body for longer, to provide anti aging benefits that help to improve your health and vitality. Additionally, carnosine and Benegene (which contains the nutrient 3-carboxy-3-oxoprpopanoic acid) offer proven life extending health benefits in reversing aging.

Curcumin, an extract of the herb turmeric, offers numerous and amazing health benefits to curb the aging process (1). Firstly, curcumin is a potent antioxidant which helps to protect the body’s cells from damage caused by harmful molecules known as free radicals. Free radicals cause permanent damage to cells impairing their function in the body. Additionally, free radicals can cause DNA damage that can be a factor in the development of cancer and other age-related disorders. Since aging is believed to be accelerated by inflammation which causes free radical damage in the body among other health problems, curcumin acts as a powerful weapon to block harmful inflammatory processes. Curcumin protects the body’s cells so they can function normally and so you can age well (2). 

Human, animal and cell studies demonstrate curcumin’s ability to help slow the progression of diseases involving inflammation and neurodegeneration (3) such as stroke, Alzheimer's, cerebral ischemia and multiple sclerosis. Research also demonstrates curcumin’s effectiveness at reducing the accumulation of beta-amyloid plaque, a substance which is toxic to brain cells and which contributes to the progression of Alzheimer’s disease (4)(5). The anti-tumor activities of various curcumin extracts have also been recognized by the research community. Additionally, curcumin helps to regulate blood pressure by lowering cholesterol levels and reducing the risk for cardiac events (6). Curcumin protects the gastrointestinal tract from ulceration (7) and provides anti-bacterial and anti-fungal benefits to help ward off illnesses (8). Overall, curcumin helps one maintain a higher level of health and facilitates healthy aging.

References: (this section)

1.) Sikora E et al. The promise of slow down ageing may come from curcumin. Curr Pharm Des. 2010;16(7):884-92.

2.) Khansari N et al. Chronic inflammation and oxidative stress as a major cause of age-related diseases and cancer. Recent Pat Inflamm Allergy Drug Discov. 2009 Jan;3(1):73-80.

3.) Greg M et al. Neuroprotective effects of curcumin. Adv Exp Med Biol. 2007; 595: 197–212.

4.) Shrikant Mishra and Kalpana Palanivelu. The effect of curcumin (turmeric) on Alzheimer's disease: An overview. Ann Indian Acad Neurol. 2008 Jan-Mar; 11(1): 13–19.

5.) Milan Fiala et al. Immunology. Innate immunity and transcription of MGAT-III and Toll-like receptors in Alzheimer's disease patients are improved by bisdemethoxycurcumin. Proc Natl Acad Sci U S A. 2007 Jul 31; 104(31): 12849–12854.

6.) Alwi I et al. The effect of curcumin on lipid level in patients with acute coronary syndrome. Acta Med Indones. 2008 Oct;40(4):201-10.

7.) Yadav SK. Turmeric (curcumin) remedies gastroprotective action. Pharmacogn Rev. 2013 Jan;7(13):42-6. 

8.) Jagetia GC and Aggarwal BB. "Spicing up" of the immune system by curcumin. J Clin Immunol. 2007 Jan;27(1):19-35. Epub 2007 Jan 9.

Almost every cell in your body contains Co-enzyme Q-10 (Co Q10) as it is made in almost all the body’s tissues. Co Q10 is essential for cells to make energy to do the work they need to do, it’s also a potent anti aging nutrient and antioxidant that protects cells and recharges other anti aging vitamins and antioxidants in the body such as anti aging vitamin C and E. 

Co Q10 is probably best known for its ability to protect the heart and is well-recognized and used for the treatment of congestive heart failure to reduce symptoms of fatigue, chest pain, dyspnea and heart palpitations. Studies show that Co-Q10 treatment was able to restore normal heart size and function in patients with congestive heart failure and was able to reduce the risk of overall mortality (1),(2). Co Q10 also helps keep the heart healthy through the aging process by benefiting patients who have high blood pressure (3) and other signs of heart disease. Additionally it improves outcomes in patients who undergo heart surgery (4),(5).

Co Q10 provides multiple anti aging benefits such as boosting immunity (6) and protecting cells from cancer, supporting remission from cancer, and improving patient outcomes and survival rates (7),(8),(9). Additionally, Co Q10 appears to slow the progressive deterioration of function in Parkinson’s Disease and Alzheimer’s disease (10),(11).

References: (this section)

1.) Mortensen SA et al. The effect of coenzyme Q10 on morbidity and mortality in chronic heart failure. Results from the Q-SYMBIO study. European Journal of Heart Failure (2013) 15 (S1), S20. 

2.) Munkholm H et al. “Coenzyme Q10 treatment in serious heart failure.” Biofactors 1999; 9(2-4): 285-9. 

3.) Burke BE et al. “Randomized, double-blind, placebo-controlled trial of coenzyme Q10 in isolated systolic hypertension.” South Med J. 2001 Nov; 94(11): 1112-7.

4.) Rosenfeldt FL et al. “Improved outcomes in coronary artery bypass graft surgery with preoperative coenzyme Q10: a randomized, double-blind, placebo controlled trial.” (In: “Coenzyme Q10 protects the aging heart against stress: studies in rats, human tissues, and patients.”). Ann N Y Acad Sci 2002 Apr; 959: 355-9; discussion 463-5. 

5.) Singh RB et al. “Randomized, double-blind placebo-controlled trial of coenzyme Q10 in patients with acute myocardial infarction.” Cardiovasc Drugs Ther. 1998 Sep; 12(4): 347-53. 

6.) Rajiv Saini. Coenzyme Q10: The essential nutrient. Pharm Bioallied Sci. 2011 Jul-Sep; 3(3): 466–467.

7.) Kokawa T, J. “Coenzyme Q10 in cancer chemotherapy – experimental studies on augmentation of the effects of masked compounds, especially in the combined chemotherapy with immunopotentiators.” J Pharm Bioallied Sci. 2011 Jul-Sep; 3(3): 466–467. Gan To Kagaku Ryoho 1983 Mar; 10(3): 768-74. 

8.) Lockwood K et al. “Apparent partial remission of breast cancer in ‘high risk’ patients supplemented with nutritional antioxidants, essential fatty acids and coenzyme Q10.” Mol Aspects Med. 1994; 15 Suppl: s231-40. 

9.) Thibault A et al. “Phase I study of lovastatin, an inhibitor of the mevalonate pathway, in patients with cancer.” Clin Cancer Res 1996 Mar; 2(3): 483-91.

10.) Shults CW et al. “Effects of Coenzyme Q10 in Early Parkinson Disease: Evidence of Slowing of the Functional Decline.” Arch Neurol. 2002 Oct; 59(10): 1541-50. 

11.) Dumont M et al. Coenzyme Q10 decreases amyloid pathology and improves behaviour in a transgenic mouse model of Alzheimer's disease. J Alzheimers Dis. 2011;27(1):211-23.  

Found in the skins of grapes, berries and other plants, resveratrol is a top antioxidant that supports proper immune system function and reduces inflammation. Having a high level of immunity and having a healthy inflammatory response is critical if you want to stay healthy as you get older (1)(2). Amazingly, resveratrol also helps to reduce the effects of aging by providing life extending benefits similar to those experienced from following a calorie restricted diet (3). 

Since maintaining a healthy body weight is so important for slowing the aging process, resveratrol is a beneficial anti aging dietary supplement to help prevent weight gain and to protect against the unhealthy effects of obesity. A study in obese men showed that resveratrol helped to reduce the proportion of large size fat cells and a study in mice showed that high doses of resveratrol help to offset the negative and accelerated aging effects of an unhealthy high-calorie diet (4). 

Anti aging supplement, Resveratrol, offers numerous anti aging benefits to promote healthy heart function such as reducing cholesterol and triglyceride levels, dilating blood vessels to lower blood pressure and reducing the formation of harmful arterial plaques that can contribute to stroke (3). Resveratrol provides anti-cancer effects that have been shown to occur at all three stages of cancer including initiation, promotion and progression (5),(6). Resveratrol also makes tumors more susceptible to conventional drug treatments used to eliminate cancer from the body (7),(8). Additionally, this anti aging food supplement helps to rid the body of toxins and carcinogens which can contribute to chronic disease and accelerated aging. Unfortunately, Resveratrol is known to decline with aging, which is why having a healthy diet and using resveratrol natural anti aging supplements is invaluable.

References: (this section)

1.) Das S et al. Anti-inflammatory responses of resveratrol. Inflamm Allergy Drug Targets. 2007 Sep;6(3):168-73

2.) Yuan J et al. Dietary intake of resveratrol enhances the adaptive immunity of aged rats. Rejuvenation Res. 2012 Oct;15(5):507-15. doi: 10.1089/rej.2012.1321.

3.) Das DK et al. Resveratrol and red wine, healthy heart and longevity. Heart Fail Rev. 2010 Sep;15(5):467-77.

4.) Konings E et al. The effects of 30 days resveratrol supplementation on adipose tissue morphology and gene expression patterns in obese men. Int J Obes (Lond). 2013 Aug 20.  

5.) Shankar S et al. Chemoprevention by resveratrol: molecular mechanisms and therapeutic potential. Front Biosci. 2007 Sep 1;12:4839-54. 

6.) Siddiqui IA et al. Resveratrol nanoformulation for cancer prevention and therapy.  Acad Sci. 2015 Aug;1348(1):20-31. 

7.) Gupta SC et al. Chemosensitization of tumors by resveratrol. Heart Fail Rev. 2010 Sep;15(5):467-77. 

8.) Patel KR et al. Clinical pharmacology of resveratrol and its metabolites in colorectal cancer patients. Cancer Res. 2010 Oct 1;70(19):7392-9.

Anti Aging antioxidants such as R-lipoic acid and N-acetyl-cysteine (NAC) are networking antioxidants, meaning that they keep other antioxidants active in the body to protect against a multitude of health conditions that can occur as one gets older. 

Both NAC and lipoic acid help to chelate toxic metals like iron and arsenic, as well as excessive trace metals like copper from the body, thereby protecting the brain and nerves from neurological damage (1). NAC also guards against numerous other environmental toxins and protects the liver from damage by toxins such as acetaminophen (2).

R lipoic acid has demonstrated life extending health benefits similar to those associated with the anti aging focused calorie restrictive diet (3). Animal studies have found that lifespan increases when test subjects are given N-acetyl-cysteine (4). R Lipoic acid is also known for its positive effects in regulating blood sugar and insulin activity, both important factors in slowing the aging process. It helps to prevent insulin resistance and protects the nerves from the damaging side effects of diabetes to benefit conditions such as neuropathy and cataracts (5),(6). As a powerful anti aging antioxidant, R lipoic acid helps protect against neurodegenerative conditions that are more prevalent in older people; studies have shown improvements in animal models of Alzheimer’s, Parkinson’s and other neurodegenerative diseases. 

NAC is known to boost immunity (7) and improves the symptoms of life-threatening respiratory conditions such as chronic obstructive pulmonary disease (8). Additionally, it has heart protective properties and prevents damage to the heart as a result of restricted blood flow to the heart due to having a stroke or heart attack (9). 

References:

1.) Margaret E. Sears. Chelation: Harnessing and Enhancing Heavy Metal Detoxification—A Review. ScientificWorldJournal. 2013; 2013: 219840.

2.) Owumi SE et al. Co-administration of N-Acetylcysteine and Acetaminophen Efficiently Blocks Acetaminophen Toxicity. Drug Dev Res. 2015 Aug;76(5):251-8.

3.) Lee CK et al. The impact of alpha-lipoic acid, coenzyme Q10 and caloric restriction on life span and gene expression patterns in mice. Free Radic Biol Med. 2004 Apr 15;36(8):1043-57.

4.) Roman V. Kondratov et al. Antioxidant N-acetyl-L-cysteine ameliorates symptoms of premature aging associated with the deficiency of the circadian protein BMAL1 Aging (Albany NY). 2009 Dec; 1(12): 979–987.

5.) Saeid Golbidi et al. Diabetes and Alpha Lipoic Acid. Front Pharmacol. 2011; 2: 69.

6.) Ziegler D et al. Alpha-lipoic acid in the treatment of diabetic peripheral and cardiac autonomic neuropathy. Diabetes. 1997 Sep;46 Suppl 2:S62-6.

7.) De Flora S et al. Attention of influenza symptomatology and improvement of cell-mediated immunity with long-term NAC treatment. Eur. Respir J; 10: 1535-1541. (1997).

8.) Anna M Sadowska et al. Role of N-acetylcysteine in the management of COPD. Int J Chron Obstruct Pulmon Dis. 2006 Dec; 1(4): 425–434.

9.) Jan Sochman, MD, PhD N-acetylcysteine in acute cardiology: 10 years later What do we know and what would we like to know?! J Am Coll Cardiol. 2002;39(9):1422-1428. 

Additional References:

10.) Brack  C et al. N-acetylcysteine slows down ageing and increases the life span of Drosophila melanogaster. Cell Mol Life Sci. 1997 Dec;53(11-12):960-6.

11.) Farshid A et al. Effects of histidine and N-acetylcysteine on doxorubicin-induced cardiomyopathy in rats. Cardiovasc Toxicol. 2014 Jun;14(2):153-61

12.) Crespo M et al. Chronic treatment with N-acetylcysteine improves cardiac function but does not prevent progression of cardiomyopathy in Syrian cardiomyopathic hamsters. J Cardiovasc Pharmacol Ther. 2011 Jun;16(2):197-204

Carnosine is the most exciting anti aging nutrient discovered. Research suggests that levels of carnosine decline with age and that more carnosine is found in the cells of longer living animals than those with shorter lifespans. In vitro studies show that carnosine helps keep cells younger and prevents distinctive changes in the shape and structure of the cells that would normally occur as the cells grow old (1),(2). Essentially, it’s been thought that carnosine keeps cells in a healthy condition and protects their DNA to ensure they function normally. 

Studies in mice demonstrate that carnosine is an incredible anti aging nutrient that keeps the animals younger mentally, behaviorally and in appearance. Additionally, carnosine fed mice lived longer and had less health problems than those not given carnosine. Animal studies also show that carnosine reduces mortality after stroke and protects against brain damage (3).  Both cell and animal studies have demonstrated that carnosine helps to destroy cancer cells and reduce tumor growth (4)(5). Studies also show that carnosine provides protection from the damaging and aging effects of a high sugar diet and preserves the integrity of blood vessels helping to mitigate blood pressure increases (6).

Test-tube studies have found that carnosine prevents amyloid beta-peptides which are associated with plaque formation in the brains of people with Alzheimer's disease, a disease many people fear they’ll get as a result of aging (7). Overall, carnosine offers a multitude of anti aging benefits that enhance health and immunity; it even protects cells against damage that occurs from a variety of toxins produced in the body as a part of normal metabolism.

References: 

1.) McFarland GA et al. Retardation of the senescence of cultured human diploid fibroblasts by carnosine. Exp Cell Res 1994 Jun; 212(2): 167-75. 

2.) Shen Y et al. Neuroprotective effect of carnosine on necrotic cell death in PC12 cells. Neurosci Lett. 2007 Mar 6;414(2):145-9.

3.) Baek S et al. Modulation of mitochondrial function and autophagy mediates carnosine neuroprotection against ischemic brain damage. Stroke. 2014 Aug;45(8):2438-43.  

4.) Miku?a-Pietrasik J et al. L-Carnosine Prevents the Pro-cancerogenic Activity of Senescent Peritoneal Mesothelium Towards Ovarian Cancer Cells. Anticancer Res. 2016 Feb;36(2):665-71.

5.) Holliday R, McFarland GA. “Inhibition of the growth of transformed and neoplastic cells by the dipeptide carnosine.” Br J Cancer. 1996 Apr; 73(8): 966-71.

6.) Hipkiss AR et al. Carnosine, the anti-ageing, anti-oxidant dipeptide, may react with protein carbonyl groups. Mech Ageing Dev. 2001 Sep 15;122(13):1431-45.

7.) Corona C et al. Effects of dietary supplementation of carnosine on mitochondrial dysfunction, amyloid pathology, and cognitive deficits in 3xTg-AD mice. PLoS One. 2011 Mar 15;6(3):e17971. re (15).

Research has revealed that certain longevity genes are activated during caloric restriction, which has an anti aging effect. Caloric restriction has been shown to delay the onset or reduce the incidence of many age-related diseases including cancer, diabetes, cardiovascular disease and neurological diseases including Parkinson’s and Alzheimer’s disease. 

What’s exciting is that taking benaGene, (which contains the anti aging nutrient and antioxidant 3-carboxy-3-oxoprpopanoic acid) the same life-extending benefits occur in the body as following a calorie restricted diet. However, these benefits are experienced without actually having to cut down on calories. 

In animal studies, benaGene increases lifespan (1),(2). Additionally, BenaGene anti aging nutritional supplements turns down the activity of genes that create and store fat. Research in mice has found benaGene anti aging natural supplements result in the same changes in gene expression as does caloric restriction (1),(2).  These gene expression changes are all known to contribute to longevity.  

Since people with diabetes seem to “age faster” than people without diabetes, because of the damage that high blood sugar causes to tissues, maintaining blood sugar balance is a key to reducing the rate of aging. Human clinical trials have confirmed reductions in glucose levels and an improved uptake of glucose in diabetic individuals and healthy subjects taking beneGene. Remarkably, fasting blood glucose levels decreased in both diabetic and healthy individuals taking benaGene anti aging supplements (3),(4).

References: (this section)

1.) Alan Cash. Modification of the NAD /NADH Ratio Via Oxaloacetic Acid Supplementation to Mimic Calorie Restriction Metabolic Pathways and Increase Lifespan" Anti-Aging Therapeutics Volume XII, American Academy of Anti-Aging Medicine, December 2010

2.) Williams DS et al. Oxaloacetate supplementation increases lifespan in Caenorhabditis elegans through an AMPK/FOXO-dependent pathway. Aging Cell. 2009 Dec;8(6):765-8.

3.) Kiyohiko Oshikawa. Studies on Antidiabetic Effect of Sodium Oxaloacetate. Tohoku J. Exp. Med. 1968, 96: 127-131.

4.) BeneGene. http://www.benagene.org/benagene_news. Web. 2009.



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