Product Details

XOS

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Xylo...What?

  • Xylo-oligosacchride is a prebiotic fibre that promotes the growth of the probiotic Bifidobacterium
  • Quickly and gently relieves constipation and diarrhea
  • Benefits digestive and metabolic health 
  • Promotes the growth of only “good” bacteria
  • Safe for long term use and safe in the 2nd and 3rd trimester of pregnancy 

 

Use this product for:

Xylo-oligosacchride (XOS) is a prebiotic fiber that promotes the growth of the probiotic Bifidobacterium. XOS is one of many different prebiotics. All prebiotics promote the growth of gut microflora, good and bad, but XOS selectively promotes the growth of only beneficial microflora, namely bifidobacteria. As the number of beneficial flora increases, they can inhibit the growth of harmful bacteria by competing with the harmful bacteria for resources. The beneficial flora can also lower the pH of the intestines to make it an inhospitable environment for harmful bacteria to live. Improved gut microflora has benefits for digestive, cardiovascular, and overall health, especially in improving occasional gastrointestinal disorders.

AOR’s XOS quickly and gently relieves occasional constipation and diarrhea. XOS can be used for the maintenance of metabolic health, and is safe for long term use, and safe in the 2nd and 3rd trimester of pregnancy.

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Discussion

XOS is a soluble prebiotic fibre that helps stimulate the growth of Bifidobacterium in the intestine.  It has been shown to help improve bowel regularity, and helps provide gentle relief from constipation and diarrhea. 

Product Variations

NPN Product Code Size
80063891 AOR04378 180 Lozenges (unflavoured)
80063892 AOR04381 180 Lozenges (Straberry)

Supplement Facts

Amount Per Serving Amount:
700 mg Xylo-oligosaccharide (XOS)
Non-medicinal ingredients: rice extract, monk fruit extract.

AOR™ guarantees that no ingredients not listed on the label have been added to the product. Contains no wheat, gluten, nuts, peanuts, sesame seeds, sulphites, mustard, soy, dairy, eggs, fish, shellfish or any animal byproduct.

Suggested Use:

Take 2-4 lozenges daily for intestinal regularity and constipation relief. Take 4-6 lozenges daily as a prebiotic for growth of Bifidobacterium. Take 5-6 lozenges for a source of fibre. Take 2 hours before or after taking other medications or natural health products, or as directed by a qualified health care practitioner. To maintain adequate fluid intake, take with at least 1 glass of water.

Cautions :

Consult a heath care practitioner prior to use if you have been pregnant for less than 23 weeks, if you are taking medications which inhibit peristaltic movement (e.g. opioids, loperamide), or if you are experiencing any of the following; sudden change in bowel habits that have persisted for more than 2 weeks, undiagnosed rectal bleeding, failure to defecate following the use of laxative products or symptoms such as abdominal pain, nausea, vomiting, or fever. Consult a health care practitioner if symptoms worsen, if laxative effect does not occur within 7 days, or for use beyond 4 weeks. May cause mild gastro-intestinal discomfort such as gas, bloating and cramps.

Pregnancy/Breastfeeding :

Consult a heath care practitioner prior to use if you have been pregnant for less than 23 weeks.

Source:

Corn cobs

Main Applications:

Digestive health
Constipation
Diarrhea
Cholesterol

 

The information and product descriptions appearing on this website are for information purposes only, and are not intended to provide or replace medical advice to individuals from a qualified health care professional. Consult with your physician if you have any health concerns, and before initiating any new diet, exercise, supplement, or other lifestyle changes.

Not all Bacteria are Bad

There are at least a 100 trillion microbes of different species that live in our gastrointestinal (GI) tract, some beneficial and some pathogenic. Probiotics, such as Bifidobacterium and Lactobacillus, are the “good” bacteria in the gut, which have beneficial effects on human health. In the early 1900s, the concept that some microorganisms can replace pathogenic microbes in the gut, and therefore improve the ecosystem in the GI tract and confer other physiological benefits, was first introduced. In recent years, there has been extensive scientific effort to “map” the microbes in the gut and understand their role in many different areas of health, wellness and the prevention of disease. It has been suggested that many degenerative diseases, GI and non-GI related, start in the gut as a result of an altered GI microflora (bacteria) where pathogenic bacteria outnumber and outperform beneficial bacteria. This has been implicated in many GI disorders such as irritable bowel syndrome (IBS), constipation and infectious diarrhea, as well as metabolic conditions including diabetes, and obesity, and also disorders of the liver, immune system and mental health. Probiotics flourish by digesting carbohydrates (prebiotics) that are indigestible by normal human enzymes, in doing so they reduce the growth of the bacteria that promotes GI disorders and disease.   

Prebiotics and Your Health

Prebiotics are plant derived fibres which are indigestible by humans and are instead fermented by intestinal microflora. This promotes the growth of the microflora and changes the composition and activity of the GI ecosystem in a beneficial way.  When the bacteria in the gut digest and ferment prebiotic fibres, they produce compounds called Short Chain Fatty Acids (SCFAs) such as butyrate, acetate, propionate and lactate. SCFAs play a key role in the body; their functions range from lubricating the GI tract, providing energy to intestinal cells, lowering pH levels (increasing acidity) to reduce the growth of pathogenic bacteria, reducing fat and cholesterol production in the liver, improving intestinal motility to reduce constipation and regulating immunity and inflammation. Prebiotics are a necessary source of energy that the bacteria need to produce these compounds and, without them, pathogenic bacteria have a more hospitable environment in which to grow. 

Xylo…What?

Xylo-oligosaccharide or XOS (z-a:-s) is a prebiotic fibre that promotes bowel regularity and digestive health. XOS is composed of a short chain of carbohydrate units, known as “oligosaccharides,” which are indigestible by humans and, therefore, non-caloric. As a prebiotic, XOS is digested by the microflora found in the intestines where it is highly effective at increasing the growth of beneficial probiotics, especially bifidobacteria, and improving the gut ecosystem to preferentially favour the growth of “good” vs “bad” bacteria. This improvement in gut ecology is beneficial to human health for a number of reasons; it regulates bowel function to prevent and/or relieve constipation and diarrhea, improves metabolic parameters such as reducing fat production in the liver, increases the excretion of cholesterol in the feces, improves nutrient absorption and improves altered gut microflora in type II diabetics. Furthermore, XOS is considered to be a source of dietary fibre, which has benefits for cardiovascular, metabolic, digestive and cellular health amongst its role in promoting bowel regularity.   

The Take Home Message

XOS is one of many different prebiotics including fruco-oligosaccharides (FOS), galacto-oligosaccharides (GOS), raffinose and inulin; however, XOS differs from these other prebiotics in a very important way. All prebiotics promote the growth of gut microflora, good and also bad, but XOS selectively promotes the growth of only beneficial microflora, namely bifidobacteria. As the number of beneficial flora increases, they can inhibit the growth of harmful bacteria by competing with them for resources and lowering the pH of the intestines to make it an inhospitable environment for them to live. XOS is considered to be one of the most beneficial prebiotics because it is highly effective at improving the GI ecosystem compared to the other prebiotics.  

The Importance of Bifidobacteria

Bifidobacterium species are some of the most abundant types of bacteria in the human colon, They are also found in the vagina and the mouth.  Bifidobacterium’s role in gastrointestinal health, and preventing the symptoms of GI disorders, has been well documented. Studies have shown that individuals with inflammatory bowel diseases display abnormal alterations in gut flora (dysbiosis) with reduced “good” bacteria, especially reduced Bifidobacterium. In these individuals, pathogenic bacteria may account for 40% of their gut ecology, a significant factor in inflammation and altered immunity. Reduced Bifidobacterium and increased pathogenic bacteria, such as E.coli, has also been observed in individuals with celiac disease, likely due to carbohydrate restriction, an important source of energy for gut flora. There are numerous strains of bifidobacteria; they have different roles in the body but all preferentially favour XOS over other types of prebiotics.  

 

Probiotics are becoming increasingly popular in the market as we begin to understand the link between gut health and the health of the rest of the body. In recent years, supplement manufactures have begun to include prebiotics such as FOS and inulin into probiotic capsules to encourage their growth; unfortunately, they are typically not in high enough amounts to cause effective growth of probiotics in the intestines. They are also impractical for everyday relief of constipation or diarrhea because they cause bloating and discomfort at high doses. Alternatively, natural laxatives such as Senna are popular because of their fast acting relief; however, long term use of many herbal laxatives is not recommended warranting the need for a safe, fast, and gentle, supplement for constipation relief which addresses the cause of the problem. 

XOS is the first xylo-oligosaccharide standalone prebiotic in Canada. Unlike other prebiotics, it promotes the growth of beneficial bacteria, namely Bifidobacterium, and relieves constipation and diarrhea quickly without the uncomfortable side effects associated with other prebiotics, laxatives and anti-diarrheals. 

XOS for Regularity

Constipation is a common digestive concern and affects many people at different points in their life. This is especially true during pregnancy due to anatomical changes of the GI tract. Constipation is a general term that clinically refers to the lack of a bowel movement in 3 days or the feeling of an incomplete bowel movement.  Constipation can be chronic or acute and can have a number of causes including obstruction, hormonal and thyroid disorders. One of the most common causes for constipation is the lack of fibre in the diet; fibre promotes the growth of probiotics and is an important component of producing bulk in the stool, which promotes peristalsis or the contraction of the colon, which allows bowel movements to occur.  Treatment involves pharmaceutical or herbal laxatives which are generally not recommended for long term use or during pregnancy as they can cause over stimulation of the colon and a habitual dependence on them. 

XOS has a 93% efficacy rate on relieving constipation. It does this by promoting the growth of bifidobacteria which is known to regulate the GI tract. It also acts as a bulking agent in the stool to promote peristalsis which can gently, but effectively, cause a bowel movement.  Even in severely constipated women, XOS supplementation produced a bowel movement within 3 days. Unlike chronic laxative use, XOS is safe long term and after the 1st trimester of pregnancy. Since it is effective in small doses compared to traditional fibre supplements and other prebiotics, it is less likely to cause gastrointestinal disturbances such as gas and bloating.     

Diarrhea

Diarrhea is the condition of loose, watery stools. Most diarrhea cases are caused by an intestinal infection by pathogenic bacteria, viruses and parasites which damage the walls of the GI tract so it can’t regulate bowel movements. Infectious diarrhea or “traveler’s diarrhea” is common when visiting developing countries and is most often acquired from contaminated food or water. Diarrhea is also a common symptom of inflammatory GI conditions such as IBS. It is believed that the increase in pathogenic bacteria in IBS individuals is the cause for the inflammation and damage to the wall of the intestinal tract. In studies, XOS was 90% effective at treating moderate diarrhea. Its effects are likely due to its ability to re-colonize the GI by selectively promoting the growth of good bacteria which reduces the population of bad bacteria and inhibits their damaging effects on the GI. 

Nutrient Absorption

One of the most interesting health benefits of XOS is its effects on improving the absorption of calcium and other nutrients in the GI tract. Many of the nutrients we supplement do not actually get 100% absorbed by the body nor do they reach their target destination; this is especially true for calcium. Calcium is an important mineral for a number of processes in the body and most popularly used to prevent osteoporosis.  When it comes to bone strength, improving calcium absorption is far more important than supplementing with more calcium. XOS improves nutrient absorption because it is fermented by gut microflora to form SCFAs; SCFAs are important compounds in nutrient absorption. SCFA’s directly enhance the absorption of calcium, iron and other minerals in the GI tract by promoting the health of intestinal cells, so they can properly absorb nutrients by lowering the pH of the intestines. This keeps the minerals in their most absorbable forms.  

Metabolic Health

Metabolic disorders, such as obesity, diabetes and abnormal cholesterol, are not only diseases of abnormal food intake; they are also connected to overall gut health. Studies have shown that individuals with obesity and type II diabetes have dysbiosis and abnormal ratio of pathogenic bacteria over healthy bacteria. In one study, diabetics supplementing with XOS had not only improved their GI bacterial flora, but also improved their short and long term blood sugar control along with their cholesterol levels.  Other studies have shown improvements in subjects’ total cholesterol levels with elevated levels of HDL, the “good” cholesterol. There are a number of proposed mechanisms for how XOS can improve metabolic parameters; it reduces the internal synthesis of lipids (fat) and lipids in the blood stream and increases the excretion of cholesterol through the feces. SCFAs can improve sugar metabolism and regulate insulin activity. 

Immunity

The connection between probiotics and immunity is well studied. Probiotics improve immunity by reducing the number of pathogenic bacteria in the GI tract and improving the gut barrier to reduce the risk of pathogens “leaking” into the circulation. XOS has an immuno-stimulatory effect by increasing the growth of the probiotics which modulate immune function and reduce pro-inflammatory and excessive immune stimulating compounds. This is especially beneficial for those with suppressed immunity such as the elderly and excess inflammation, as in the case of allergies. 

 

Chinese Journal of Abdominal Diseases, October 2003, Vol. 3, No. 10


Finegold, Sydney M., Zhaoping Li, Paula H. Summanen, Julia Downes, Gail Thames, Karen Corbett, Scot Dowd, Michael Krak, and David Heber. "Xylooligosaccharide increases bifidobacteria but not lactobacilli in human gut microbiota." Food & function 5, no. 3 (2014): 436-445.

Jeanne A. Drisko, Cheryl K. Giles, Bette J. Bischoff. "Probiotics in health maintenance and disease prevention". Altern Med Rev. 2003 May; 8(2): 143–155.

Jolanta Sarowska, Irena Choroszy-Król, Bo?ena Regulska-Ilow, Magdalena Frej-M?drzak, Agnieszka Jama-Kmiecik. "The therapeutic effect of probiotic bacteria on gastrointestinal diseases." Adv Clin Exp Med. 2013 Sep-Oct; 22(5): 759–766.

IINO Taeko, Yasufumi NISHIJIMA, Sachiko SAWADA, Hiroaki SASAKI, Hitoshi HARADA, Yoshihide SUWA, and  Yoshinobu KISO. "Improvement of constipation by a small amount of xylooligosaccharides ingestion in adult women." Japanese Association for Dietary Fiber Vol. 1, no. 1 (1997): 19-24

Na, M. H., & Kim, W. K. (2007). Effects of xylooligosaccharide intake on fecal bifidobacteria, lactic acid and lipid metabolism in Korean young women. Korean Journal of Nutrition, 40(2), 154-161.

Shanghai XOS Collaboration Group In house study, 2011

Sheu, Wayne Huey-Herng, I-Te Lee, Wei Chen, and Yin-Ching Chan. "Effects of xylooligosaccharides in type 2 diabetes mellitus." Journal of nutritional science and vitaminology 54, no. 5 (2008): 396-401

Tateyama, Ichiro, Koji HAsHII, Ikuo Johno, Taeko IINO, Kouichi HIRAI, Yoshihide SUWA, and Yoshinobu KIso. "Effect of xylooligosaccharide intake on severe constipation in pregnant women." Journal of nutritional science and vitaminology 51, no. 6 (2005): 445-448.

 

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