Product Details

ADVANCED FRACTURE SUPPORT

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Accelerate Your Recovery

  • Helps bone fractures heal faster
  • Speeds healing time by up to 40%
  • Improves bone quality after a fracture
  • Contains a clinically studied combination of Ayurvedic herbs

Use this product for:

Advanced Fracture Support is suitable for people who want to speed healing from bone fractures or surgeries, as well as those with osteopenia and osteoporosis who are looking to improve bone health and increase bone density. Sufferers of all types of muscle and joint injuries, from bodybuilders to the elderly, may also want to use Advanced Fracture Support to help accelerate their healing. 

Advanced Fracture Support contains a clinically studied combination of Ayurvedic herbs, including Veldt grape, holy basil, and ashwagandha extracts, to help accelerate bone repair and improve bone quality after a fracture. Advanced Fracture support features Cissus quadrangularis (CQ or Veldt grape extract) and is a powerful formula to support the healing of bone fractures and provide support for those with weakened bones. Clinical studies have found that it accelerates bone healing by up to 30-40% and reduces the amount of time a fracture is required to be immobilized. This means that you can get back to your regular activities sooner! Holy basil and ashwagandha are adaptogenic herbs that help regulate the stress response, immunity and inflammation, which are important for proper healing. 

AOR is the first to provide this clinically studied combination of herbs in one supplement. Advanced Fracture Support is an herbal formula, making it suitable for vegans and ideal for those not wanting to take large doses of calcium or dairy products. Minimal to no side effects have been reported among users. It is often used by bodybuilders to help heal lifting injuries to reduce pain and improve range of motion. 

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Discussion

Advanced Fracture Support contains Cissus quadrangularis, which is traditionally used in Ayurvedic medicine to help in healing bone fractures.

Product Variations

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Supplement Facts

Amount Per Serving Amount: 1 Capsule
250 mg Veldt Grape extract (Cissus quadrangularis 20:1)
125 mg Holy Basil extract (Ocimum tenuiflorum 10:1)
187.5 mg Ashwagandha extract (Withania somnifera 10:1)*
*Typically 2.5% withanolides, 0.1% sitoindosides.
Non-medicinal ingredients: sodium stearyl fumarate, maltodextrin, microcrystalline cellulose, silicon dioxide. Capsule: hypromellose.

AOR™ guarantees that all ingredients have been declared on the label. Contains no wheat, gluten, nuts, peanuts, sesame seeds, sulphites, mustard, soy, dairy, eggs, fish, shellfish or any animal byproduct.

Suggested Use:

(Adult): Take 1 capsule one to three times daily with/without food, or as directed by a qualified health care practitioner.

Cautions :

Do not use if you are pregnant, breastfeeding or trying to conceive. Consumption of ashwagandha with alcohol or other drugs or natural health products with sedative properties is not recommended. Consult a health care practitioner prior to use if you have diabetes, if you are taking any heart or blood pressure medications or for use beyond 4 weeks.

Pregnancy/Breastfeeding :

Source:

Natural botanical extracts

Main Applications:

  • Fracture healing
  • Bone health
  • Joint pain/injuries
  • Weight management
  • Cardiovascular health

The information and product descriptions appearing on this website are for information purposes only, and are not intended to provide or replace medical advice to individuals from a qualified health care professional. Consult with your physician if you have any health concerns, and before initiating any new diet, exercise, supplement, or other lifestyle changes.

Advanced Fracture support features Cissus quadrangularis (CQ) and is a powerful formula to support the healing of bone fractures and provide support for those with weakened bones. Clinical studies have found that it accelerates healing by up to 30-40% and reduces the amount of time a fracture is required to be immobilized. This means that you can get back to your regular activities sooner!

A Completely Herbal Formula for Bone Health

Advanced Fracture Support provides the vine extract Cissus quadrangularis (CQ), also known as veldt grape, combined with the Ayurvedic herbs holy basil and ashwagandha. Holy basil and ashwagandha are also adaptogenic herbs that help regulate the stress response, immunity and inflammation, which are important for proper healing. Advanced Fracture Support contains a complex of ingredients that are proven to support the building of bone.  

Traditional Uses

CQ is a vine with rectangular joints in the stems that resemble those of a cactus. It has been used in Ayurvedic medicine for hundreds of years for a variety of uses. In the Ayurvedic Pharmacopoeia of India, the dried stem of Cissus quadrangularis at 3-6 g of powder per day is listed as having numerous therapeutic purposes, including “asthisandhanakra” which is translated to “bone fracture healing.” CQ’s Sanskrit name, Hadjod, literally means “bone-union,” and Ayurvedic physicians refer to it as the “bone-setter.” A survey on traditional medical practices of certain tribal groups in India revealed that CQ is also used to reduce the symptoms of rheumatism. About ten grams of a paste made from the tender shoots is consumed twice a day for three weeks for rheumatism.

Modern Uses

CQ is used to support bone health and heal fractures. CQ has also been reported to reduce chronic joint pain caused by strenuous exercise, and it is often used by gym-goers to accelerate tissue healing and reduce joint pain resulting from gym workouts, for back pain, knee pain, strains and tendonitis, and by people recovering from surgeries, all with very positive results.

People who have taken Cissus quadrangularis or products containing it have noted significant reductions in joint pain like tendonitis, rotator cuff, spinal disc problems or joint surgery, muscle pain like tension headaches, and faster recovery from injuries. Some call it a miracle product. Side effects include improving cholesterol and triglycerides. Minimal to no negative side effects have been reported among users. It is often used by bodybuilders to help heal lifting injuries, to reduce pain and improve range of motion.

 

Healing bone and musculoskeletal problems can involve the use of pain relieving and anti-inflammatory medications. However, until now, no supplements have been known to accelerate fracture healing.

AOR is the first to provide this clinically studied combination of herbs in one supplement. Advanced Fracture Support is an herbal formula, making it suitable for vegans and ideal for those not wanting to take large doses of calcium or dairy products. Few to no adverse effects have been reported, and Cissus quadrangularis has amazing additional health benefits for metabolism, cardiovascular health and more.

Cissus quadrangularis (CQ) To Accelerate Healing

An open study demonstrating the effectiveness of Cissus quadrangularis used 60 patients with simple as well as closed fractures of long bones. They were treated topically with cissus quadrangularis. The average healing time for these patients, which is known to be normally 16-20 weeks, was reduced to 12-14 weeks in the treated group, thereby accelerating fracture healing by 30-40%.

Improved Bone Mass Density

A trial was conducted to evaluate efficacy of the combination of ashwagandha, holy basil and Cissus quadrangularis in low BMD patients. This was a prospective, double blind, randomized, placebo controlled trial. First 30 low BMD patients who gave informed consent and fulfilled the selection criteria, were randomly entered in the trial, to receive the medicine in a dose of three capsules daily for six months. BMD assessed by DEXA scan, estimation of serum alkaline phosphatase, calcium and phosphorus were done at baseline and after six months of intervention. There was a significant improvement in bone density in the herbal combination treated patients. There was significant reduction in serum alkaline phosphatase in herbal combination group, a marker of bone loss. The herbal combination showed statistically significant beneficial effects on BMD without any adverse risks. 

A study was conducted to evaluate efficacy of a proprietary formula which contained Cissus quadrangularis in perimenopausal low bone mineral density women, and to evaluate the safety and tolerability of this formula. The study gave 250 mg of the formula, three times daily, to 40 perimenopausal women for 6 months. The bone mineral density was increased by 17% and the bone density test scores (T and Z ) were significantly increased after 6 months.

Decreased Joint Pain

A study in 29 men between the ages of 20 and 46 years, who reportedly experienced chronic joint pain as a result of strenuous exercise, participated in a pilot study. All men received CQ 3200 mg daily for 8 weeks. Before and after the 8-week intervention period, subjects completed a questionnaire to determine their degree of joint pain (Western Ontario and McMaster Universities Index of Osteoarthritis [WOMAC]). Clinical measures included heart rate, blood pressure and blood biomarkers were also collected for each subject pre-baseline and post-intervention. An 8-week course of supplementation with CQ reduced joint pain in a sample of 29 young, otherwise healthy, exercise-trained men.

Improved Metabolic Measures

Several clinical studies have also shown that CQ reduces body weight, supports a healthy metabolism, blood sugar levels and improves cholesterol. In one such study, a proprietary formulation containing Cissus Quadrangularis brought about significant reductions in weight and blood glucose levels, while decreasing serum lipids thus improving cardiovascular risk factors.

Ashwaghanda for Bone Health

In vitro, ashwagandha has been demonstrated to exert a positive effect on osteoblasts (cells that build bone) by increasing osteoblast proliferation and differentiation. It increased expression of osteoblast-specific proliferation factors and mineralizing genes, promoted osteoblast survival and suppressed inflammatory cells. Ashwaghanda treatment also decreased osteoclast (cells that break down bone) numbers.

In vivo, oral administration of ashwagandha to osteopenic ovariectomized mice increased cells that assist in the growth and repair in the bone marrow and increased expression of bone growth genes. Ashwagandha supplementation improved trabecular micro-architecture of the long bones, increased biomechanical strength parameters of the vertebra and femur, decreased bone turnover markers (osteocalcin and TNFα) and expression of bone breakdown genes. It also increased new bone formation and expression of bone forming genes in the femur bone.

Ashwaghanda for Stress and Anxiety

Ashwagandha has traditionally been used as an Ayurvedic remedy for anxiety, an effect well documented in animal models. In a controlled study in humans stressed with repeated, heavy swimming, people taking ashwagandha were better protected against gastric damage, depletion of vitamin C, and exhaustion of a key adrenal hormone, and had increased physical endurance compared with people taking Panax ginseng. Similar studies have shown that providing lab animals with ashwagandha leads to better stress tolerance, longer swimming times, improved maintenance of glycogen energy stores, the development of more heart muscle mass, protection against the shrinking of the adrenals and the depletion of vitamin C, and more muscle weight gains.

Holy Basil’s Benefits During Healing

Holy basil has been reported to induce relaxation, promote a feeling of calm and reduce stress. One Indian study examined this effect in anxious patients, as anxiousness is a central precursor to stress. Thirty-five individuals (21 male and 14 female between the ages of 18-60) were given 500 mg of holy basil twice daily for 60 days. The subjects consisted of people from various professions and walks of life, which is important considering the role played by social status in determining levels of anxiousness and stress. Patient progress was measured according to the seven point scoring system of the modified Hamilton’s brief psychiatric rating scale. According to these standardized index scores, mood, anxiousness and stress were improved by 13.2%, 19.2%, and 11.5% respectively.

Anti-inflammatory and Pain Relieving Action

Research has also shown that holy basil is a very effective anti-inflammatory. In laboratory rats, for example, holy basil reduced paw edema (swelling) by 66%. This seems to be due to the inhibition of the enzyme COX-2 by eugenol, which may also explain holy basil’s capabilities as an analgesic (pain-reliever). COX-2 inhibition is a mechanism common to numerous painkillers.

 

 

 

Bloomer RJ, Farney TM, McCarthy CG, Lee SR. Cissus quadrangularis reduces joint pain in exercise-trained men: a pilot study. Phys Sportsmed. 2013 Sep;41(3):29-35.

Deshmukh VS, Khot RS, Thawani WR, Abichandani LG, Goswani SS. Efficacy of Cissus Quadrangularis (Calzbone®) in Perimenopausal, Low Bone Density Women. The Antiseptic, 2011; 504-506.

Dhatrak Sarang, Thawani Vijay, Gharpure Kunda, Apte Indrayani, Masand Anil, Hingorani Lal, and Khiyani Raj, Effect of Herbal Combination in Low Bone Mass Density Patients. International Journal of Drug Discovery and Technology. 2011; 2(1): 9-14

Government of India, Ministry of Health and Family Welfare, Department of Ayush. THE AYURVEDIC PHARMACOPOEIA OF INDIA. Part I, Volume III. Page 21-22.

Gupta AK, Shah N, Thakar AB. Effect of Majja Basti (therapeutic enema) and Asthi Shrinkhala (Cissus quadrangularis) in the management of Osteoporosis (Asthi-Majjakshaya). Ayu. 2012 Jan;33(1):110-3.

Khedgikar V, Kushwaha P, Gautam J, Verma A, Changkija B, Kumar A, Sharma S, Nagar GK, Singh D, Trivedi PK, Sangwan NS, Mishra PR, Trivedi R. Withaferin A: a proteasomal inhibitor promotes healing after injury and exerts anabolic effect on osteoporotic bone. Cell Death Dis. 2013 Aug 22;4:e778.

Muthusami S, Ramachandran I, Krishnamoorthy S, Govindan R, Narasimhan S. Cissus quadrangularis augments IGF system components in human osteoblast like SaOS-2 cells. Growth Horm IGF Res. 2011 Dec;21(6):343-8.

Nagareddy PR, Lakshmana M. Withania somnifera improves bone calcification in calcium-deficient ovariectomized rats. J Pharm Pharmacol. 2006 Apr;58(4):513-9.

Oben J, Kuate D, Agbor G, Momo C, Talla X. The use of a Cissus quadrangularis formulation in the management of weight loss and metabolic syndrome. Lipids Health Dis. 2006; 5:24.

Oben JE, Enyegue DM, Fomekong GI, Soukontoua YB, Agbor GA. The effect of Cissus quadrangularis (CQR-300) and a Cissus formulation (CORE) on obesity and obesity-induced oxidative stress. Lipids Health Dis. 2007 Feb 4;6:4.

Oben JE, Ngondi JL, Momo CN, Agbor GA, Sobgui CS. The use of a Cissus quadrangularis/Irvingia gabonensis combination in the management of weight loss: a double-blind placebo-controlled study. Lipids Health Dis. 2008 Mar 31;7:12.

Potu BK, Bhat KM, Rao MS, Nampurath GK, Chamallamudi MR, Nayak SR, Muttigi MS. Petroleum ether extract of Cissus quadrangularis (Linn.) enhances bone marrow mesenchymal stem cell proliferation and facilitates osteoblastogenesis. Clinics (Sao Paulo). 2009;64(10):993-8.

Rani S.L, Devi V.K, Soris P.T, Maruthupandian A. and Mohan V.R. Ethnomedicinal plants used by Kanikkars of Agasthiarmalai Biosphere Reserve, Western Ghats. Journal of Ecobiotechnology, 2011; 3 (7):16-25.

Thawani V, Kimmatkar N, Hingorani L, Khiyani R. Effect of herbal combination containing Cissus quadrangularis in fracture healing. The Antiseptic; 2002; 99(9): 345-347.

 

Withaferin A: a proteasomal inhibitor promotes healing after injury and exerts anabolic effect on osteoporotic bone.

Cell Death Dis. 2013 Aug 22;4:e778.

Khedgikar V, Kushwaha P, Gautam J, Verma A, Changkija B, Kumar A, Sharma S, Nagar GK, Singh D, Trivedi PK, Sangwan NS, Mishra PR, Trivedi R.

Withania somnifera or Ashwagandha is a medicinal herb of Ayurveda. Though the extract and purified molecules, withanolides, from this plant have been shown to have different pharmacological activities, their effect on bone formation has not been studied. Here, we show that one of the withanolide, withaferin A (WFA) acts as a proteasomal inhibitor (PI) and binds to specific catalytic β subunit of the 20S proteasome. It exerts positive effect on osteoblast by increasing osteoblast proliferation and differentiation. WFA increased expression of osteoblast-specific transcription factor and mineralizing genes, promoted osteoblast survival and suppressed inflammatory cytokines. In osteoclast, WFA treatment decreased osteoclast number directly by decreasing expression of tartarate-resistant acid phosphatase and receptor activator of nuclear factor kappa-B (RANK) and indirectly by decreasing osteoprotegrin/RANK ligand ratio. Our data show that in vitro treatment of WFA to calvarial osteoblast cells decreased expression of E3 ubiquitin ligase, Smad ubiquitin regulatory factor 2 (Smurf2), preventing degradation of Runt-related transcription factor 2 (RunX2) and relevant Smad proteins, which are phosphorylated by bone morphogenetic protein 2. Increased Smurf2 expression due to exogenous treatment of tumor necrosis factor α (TNFα) to primary osteoblast cells was decreased by WFA treatment. This was corroborated by using small interfering RNA against Smurf2. Further, WFA also blocked nuclear factor kappa-B (NF-kB) signaling as assessed by tumor necrosis factor stimulated nuclear translocation of p65-subunit of NF-kB. Overall data show that in vitro proteasome inhibition by WFA simultaneously promoted osteoblastogenesis by stabilizing RunX2 and suppressed osteoclast differentiation, by inhibiting osteoclastogenesis. Oral administration of WFA to osteopenic ovariectomized mice increased osteoprogenitor cells in the bone marrow and increased expression of osteogenic genes. WFA supplementation improved trabecular micro-architecture of the long bones, increased biomechanical strength parameters of the vertebra and femur, decreased bone turnover markers (osteocalcin and TNFα) and expression of skeletal osteoclastogenic genes. It also increased new bone formation and expression of osteogenic genes in the femur bone as compared with vehicle groups (Sham) and ovariectomy (OVx), Bortezomib (known PI), injectible parathyroid hormone and alendronate (FDA approved drugs). WFA promoted the process of cortical bone regeneration at drill-holes site in the femur mid-diaphysis region and cortical gap was bridged with woven bone within 11 days of both estrogen sufficient and deficient (ovariectomized, Ovx) mice. Together our data suggest that WFA stimulates bone formation by abrogating proteasomal machinery and provides knowledge base for its clinical evaluation as a bone anabolic agent.

 

Cissus quadrangularis reduces joint pain in exercise-trained men: a pilot study.

Phys Sportsmed. 2013 Sep;41(3):29-35.

Bloomer RJ, Farney TM, McCarthy CG, Lee SR.

BACKGROUND: Strenuous, high-volume exercise is often associated with inflammation and joint pain. Cissus quadrangularis (CQ) has been reported to have anti-inflammatory activity. The purpose of our study was to determine the therapeutic effects of CQ supplementation in healthy, exercise-trained men with joint-specific pain.

METHODS: Twenty-nine men between the ages of 20 and 46 years, who reportedly experienced chronic joint pain as a result of strenuous exercise, participated in our pilot study. All men received CQ 3200 mg daily for 8 weeks. Before and after the 8-week intervention period, subjects completed a questionnaire to determine their degree of joint pain (Western Ontario and McMaster Universities Index of Osteoarthritis [WOMAC]). Clinical measures (eg, heart rate, blood pressure, blood biomarkers) were also collected for each subject pre- (baseline) and post-intervention.

RESULTS: Subject ratings for multiple variables within the WOMAC Index improved (decreased) significantly (P < 0.05), with the subject mean total WOMAC score decreasing from 25.4 ± 2.4 to 17.4 ± 2.1 (~31%), pre- to post-intervention. No clinical measure was significantly impacted by use of CQ supplementation.

CONCLUSION: An 8-week course of supplementation with CQ reduced joint pain in a sample of 29 young, otherwise healthy, exercise-trained men. Additional study is needed to extend these findings, including comparison with a placebo-controlled cohort, and possibly, examining effects of CQ use in women and older adult subjects.

 

Effect of Majja Basti (therapeutic enema) and Asthi Shrinkhala (Cissus quadrangularis) in the management of Osteoporosis (Asthi-Majjakshaya).

Ayu. 2012 Jan;33(1):110-3.

Gupta AK, Shah N, Thakar AB.

Osteoporosis is a systemic disorder that affects entire skeleton, which is a metabolic bone disease characterized by low bone mass and microarchitectural deterioration of the skeleton, leading to enhanced bone fragility and a consequent increase in fracture risk. In Ayurveda, it can be correlated with Asthi-Majjakshaya. Basti (therapeutic enema) is the prime therapy for Asthi related diseases and Asthi Shrinkhala (Cissus quadrangularis) is the drug which is being used for strengthening of bone by traditional Vaidya since long. It has been selected for oral administration. In clinical trial, 12 patients treated with Majja Basti along with Asthi Shrinkhala pulp capsules and results are very encouraging.

 

Effect of herbal combination in low bone mass density patients.

Int. J. of Drug Disc. & Tech. 2011 2(1):9-14.

Dhatrak S, Thawani V, Gharpure K, Indrayani A, Masand A, Hingorani L, Khiyani R. 

To evaluate the efficacy of the herbal combination containing Cissus quadrangularis, Withania somnifera and Ocimum sanctum on bone mineral density (BMD) and biochemical parameters in low MBD patients. Osteoporosis and osteopenia cause reduction in BMD, leading to skeletal fragility, thereby increasing the fracture risk. Herbal combination containing Cissus quadrangularis (CQ) has been used in traditional medicine since ages for bone related problems. Withania somnifera (WS) is used as rejuvenator. Ocimum sanctum (OS) is used as stress reliever. Hence this trial was conducted to evaluate efficacy of this herbal combination in low BMD patients. It was a prospective, double blind, randomized, placebo controlled trial carried out in Government Medical College Nagpur. First 30 low BMD patients who gave informed consent and fulfilled the selection criteria, were randomly entered in the trial, to receive the medicine in a dose of three capsules daily for six months. BMD by DEXA scan, estimation of serum alkaline phosphatase, calcium and phosphorus were done at baseline and after six months of intervention. There was a significant improvement in bone density viz. BMD, T score and Z score in herbal combination treated patients. There was significant reduction in serum alkaline phosphatase in herbal combination group. The herbal combination showed statistically significant beneficial effect on BMD without any ADRs.

 

The effect of Cissus quadrangularis (CQR-300) and a Cissus formulation (CORE) on obesity and obesity-induced oxidative stress.

Lipids Health Dis. 2007 Feb 4;6:4.

Oben JE, Enyegue DM, Fomekong GI, Soukontoua YB, Agbor GA.

AIM: Obesity is generally linked to complications in lipid metabolism and oxidative stress. The aim of this study was to compare the effect of a proprietary extract of Cissus quadrangularis (CQR-300) to that of a proprietary formulation containing CQR-300 (CORE) on weight, blood lipids, and oxidative stress in overweight and obese people.

METHODS: The first part of the study investigated the in vitro antioxidant properties of CQR-300 and CORE using 3 different methods, while the second part of the study was a double-blind placebo controlled design, involving initially 168 overweight and obese persons (38.7% males; 61.3% females; ages 19-54), of whom 153 completed the study. All participants received two daily doses of CQR-300, CORE, or placebo and were encouraged to maintain their normal levels of physical activity. Anthropometric measurements and blood sampling were done at the beginning and end of the study period.

RESULTS: CQR-300 as well as CORE exhibited antioxidant properties in vitro. They also acted as in vivo antioxidants, bringing about significant (p < 0.001) reductions in plasma TBARS and carbonyls. Both CQR-300 and CORE also brought about significant reductions in weight, body fat, total cholesterol, LDL-cholesterol, triglycerides, and fasting blood glucose levels over the respective study periods. These changes were accompanied by a significant increase in HDL-cholesterol levels, plasma 5-HT, and creatinine.

CONCLUSION: CQR-300 (300 mg daily) and CORE (1028 mg daily) brought about significant reductions in weight and blood glucose levels, while decreasing serum lipids thus improving cardiovascular risk factors. The increase in plasma 5-HT and creatinine for both groups hypothesizes a mechanism of controlling appetite and promoting the increase of lean muscle mass by Cissus quadrangularis, thereby supporting the clinical data for weight loss and improving cardiovascular health.

 

Withania somnifera improves bone calcification in calcium-deficient ovariectomized rats.

J Pharm Pharmacol. 2006 Apr;58(4):513-9.

Nagareddy PR, Lakshmana M.

Osteoporosis, characterized by reduction in bone density, is a significant source of mortality among the elderly, particularly in oestrogen-deficient women. We studied the effect of Withania somnifera (WS) root extract (ethanolic), which contains oestrogen-like withanolides for anti-osteoporotic activity. Female Sprague-Dawley rats were either sham operated (n = 12) or ovariectomized (n = 12) and treated with WS/vehicle (65 mg kg(-1)), orally for 16 weeks (n = 12). All rats were allowed free access to a calcium-deficient diet (0.04% Ca) and distilled water. At termination, urinary excretion of calcium (Ca) and phosphorus (P) and serum levels of Ca, P and alkaline phosphatase (ALP) were measured. Femur and tibia bones were processed for histological (histology), morphological (scanning electron microscopy, SEM), biomechanical strength (impact test) and mineral composition (ash) analysis. Ovariectomized (OVX) rats showed a significant increase in serum ALP levels and urinary Ca and P excretion. Histological findings revealed narrowed, and disappearance of, trabeculae with widened medullary spaces in the OVX group. Ash analysis showed a reduction in ash weight, percent ash, ash Ca, ash P and ash magnesium levels in the OVX group. Further, SEM examination revealed metaphyseal bone loss in femurs and impact test showed a reduction in biomechanical strength of tibias in OVX rats. WS treatment markedly prevented the above changes in OVX rats and thus may be a potential agent in the treatment of osteoporosis.

 

The use of a Cissus quadrangularis formulation in the management of weight loss and metabolic syndrome.

Lipids Health Dis. 2006 Sep 2;5:24.

Oben J, Kuate D, Agbor G, Momo C, Talla X.

AIM: Once considered a problem of developed countries, obesity and obesity-related complications (such as metabolic syndrome) are rapidly spreading around the globe. The purpose of the present study was to investigate the use of a Cissus quadrangularis formulation in the management of metabolic syndrome, particularly weight loss and central obesity.

METHODS: The study was a randomized, double-blind, placebo-controlled design involving 123 overweight and obese persons (47.2% male; 52.8% female; ages 19-50). The 92 obese (BMI >30) participants were randomized into three groups; placebo, formulation/no diet, and formulation/diet (2100-2200 calories/day). The 31 overweight participants (BMI = 25-29) formed a fourth (no diet) treatment group. All participants received two daily doses of the formulation or placebo and remained on a normal or calorie-controlled diet for 8 weeks.

RESULTS: At the end of the trial period, statistically significant net reductions in weight and central obesity, as well as in fasting blood glucose, total cholesterol, LDL-cholesterol, triglycerides, and C-reactive protein were observed in participants who received the formulation, regardless of diet.

CONCLUSION: Cissus quadrangularis formulation appears to be useful in the management of weight loss and metabolic syndrome.

 

The effect of Cissus quadrangularis (CQR-300) and a Cissus formulation (CORE) on obesity and obesity-induced oxidative stress.

Lipids Health Dis. 2007 Feb 4;6:4.

Oben JE, Enyegue DM, Fomekong GI, Soukontoua YB, Agbor GA

AIM: Obesity is generally linked to complications in lipid metabolism and oxidative stress. The aim of this study was to compare the effect of a proprietary extract of Cissus quadrangularis (CQR-300) to that of a proprietary formulation containing CQR-300 (CORE) on weight, blood lipids, and oxidative stress in overweight and obese people.

METHODS: The first part of the study investigated the in vitro antioxidant properties of CQR-300 and CORE using 3 different methods, while the second part of the study was a double-blind placebo controlled design, involving initially 168 overweight and obese persons (38.7% males; 61.3% females; ages 19-54), of whom 153 completed the study. All participants received two daily doses of CQR-300, CORE, or placebo and were encouraged to maintain their normal levels of physical activity. Anthropometric measurements and blood sampling were done at the beginning and end of the study period.

RESULTS: CQR-300 as well as CORE exhibited antioxidant properties in vitro. They also acted as in vivo antioxidants, bringing about significant (p < 0.001) reductions in plasma TBARS and carbonyls. Both CQR-300 and CORE also brought about significant reductions in weight, body fat, total cholesterol, LDL-cholesterol, triglycerides, and fasting blood glucose levels over the respective study periods. These changes were accompanied by a significant increase in HDL-cholesterol levels, plasma 5-HT, and creatinine.

CONCLUSION: CQR-300 (300 mg daily) and CORE (1028 mg daily) brought about significant reductions in weight and blood glucose levels, while decreasing serum lipids thus improving cardiovascular risk factors. The increase in plasma 5-HT and creatinine for both groups hypothesizes a mechanism of controlling appetite and promoting the increase of lean muscle mass by Cissusquadrangularis, thereby supporting the clinical data for weight loss and improving cardiovascular health.

 

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