Product Details

ADVANCED PCOS RELIEF

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Reduces Symptoms of PCOS 

  • Ideal ratio of two forms of inositol for improved insulin resistance, and mood 
  • Promotes healthy ovarian function and improves egg quality
  • Normalizes menstrual cycle and reverses some causes of infertility
  • Active form of folic acid for healthy reproductive, hormonal, heart and brain function

 

Use this product for:

What is PCOS?

Polycystic ovarian syndrome is a hormonal disorder affecting 5-10% of childbearing women and is the most significant cause of infertility amongst women of all nationalities. Symptoms vary greatly between women, but can include weight gain, acne, excessive hair growth, multiple ovarian cysts, and male pattern hair-loss. More serious manifestations include: hyperinsulinemia, elevated triglycerides, and difficulty breathing. A strong correlation exists between obesity, type 2 diabetes, use of valproic acid (an antiepileptic medication), and increased risk for developing PCOS. Further, there appears to be a strong genetic component to the development of PCOS.

 

How do you treat it?

Conventional treatments for PCOS are targeted to symptom management from oral retinoid for skin concerns, oral contraceptives, or insulin regulating drugs. However, the most effective treatment is always to address the root cause - this includes diet and lifestyle adjustments as well as supplementation with a few key nutrients that can improve outcomes. The first is inositol. This member of the B vitamin family comes in two forms: myo-inositol and d-chiro- inositol. A combination of these two forms was shown to significantly improve insulin sensitivity by cells, thus preventing blood glucose dysregulation. This also had an impact on the regulation of a number of sex hormone levels. Further, oocyte and egg quality improved leading to improved fertility in women suffering from PCOS. Folic acid has also been seen to be beneficial by providing antioxidant support from excess homocysteine. It also supports healthy brain, cardiovascular and genetic functioning. Advanced PCOS Relief contains the active form of folic acid  to ensure that the body can use  it properly, since it is common to have mutations in the mechanism that activates folic acid. 

 

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Discussion

Advanced PCOS Relief helps normalize ovarian function, ovulation, and oocyte quality, and normalizes menstrual cycle irregularities in women with PCOS. Advanced PCOS Relief also improves hormonal and metabolic conditions, and improves insulin sensitivity. In addition, it helps restore pregnancy rates in women under 36 with PCOS who undergo in vitro fertilization.

Product Variations

NPN Product Code Size
80066991 AOR04366 120 Softgels

Supplement Facts

Amount Per Serving Amount: 2 Softgels
200 mcg Folic acid (from calcium L-5-MTHF)
550 mg Myo-Inositol
13.8 mg D-Chiro-inositol
Non-medicinal ingredients: rice bran oil, beeswax, sunflower lecithin, tocopherols (sunflower). Softgel: cornstarch, glycerin, purified water, carrageenan, sorbitol, caramel

AOR™ guarantees that no ingredients not listed on the label have been added to the product. Contains no wheat, gluten, nuts, peanuts, sesame seeds, sulphites, mustard, soy, dairy, eggs, fish or shellfish.

Suggested Use:

Take 2 softgels two to four times per day with or without food, or as directed by a qualified health care practitioner. Use for a minimum of 12 weeks to see beneficial effects.

Cautions :

To ensure a timely treatment of a serious cause of infertility, consult a health care practitioner prior to use. Consult a health care practitioner prior to use if you are pregnant, breastfeeding, or if symptoms persist or worsen.

Pregnancy/Breastfeeding :

Source:

Main Applications:

Polycystic Ovarian Syndrome

Infertility

Acne

Facial Hair Growth

Glucose Management and Regulation

Mood: Depression, Irritability

 

The information and product descriptions appearing on this website are for information purposes only, and are not intended to provide or replace medical advice to individuals from a qualified health care professional. Consult with your physician if you have any health concerns, and before initiating any new diet, exercise, supplement, or other lifestyle changes.

Polycystic ovarian syndrome is a constellation of signs and symptoms that result from disordered endocrine function. While the exact cause is unknown, women suffering from PCOS have increased levels of androgens, or “male hormones” such as testosterone. Like most endocrine disorders, clinical signs and symptoms are highly variable between women. This hormone dysregulation has a significant impact on fertility since women have difficulty ovulating, which can lead to the development of ovarian cysts, hence the name. However, these cysts may not be present as seen in the non-classic presentations. The diagnostic criteria for PCOS include at least two of the following: 1) light or no menses which may result in infertility or multiple miscarriages, 2) clinical or biochemical signs of hyperandrogenism (including excess coarse hair growth, male pattern baldness, and/or acne), 3) polycystic ovaries. Further, there is a strong link with insulin resistance and PCOS. Other symptoms include: weight gain - particularly an increase in abdominal fat, the development of dark skin patches, elevated lipid levels, difficulty breathing, depression, and pelvic pain from abnormal ovary size and shape. The psychological effects of PCOS are also significant, including depression, anxiety, and body dysmorphia.

 

Risk factors

The exact cause of PCOS is still unclear; however, some key risk factors and related conditions have been identified. The first major risk factor is genetics; there is a strong (up to 50%) risk of developing PCOS with a first degree association with a family member who also has PCOS. A number of genes have been linked to PCOS though there is no consensus yet on which mutations will result in the hormonal dysregulation seen in this condition. Obesity is another risk factor for PCOS, while weight gain is a common symptom of PCOS. Stress can also increase the risk for atypical PCOS, since it can disturb the hypothalamic pituitary axis (HPA) lowering most sex hormones. Further, insulin resistance creates a vicious cycle where more insulin in the bloodstream promotes androgen production, which then exacerbates insulin resistance. This upsets the delicate hormone balance in the body having widespread systemic effects.

 

Insulin resistance, hormones and ovarian health:

Complex mechanisms exist within the body to ensure the distribution and release of hormones is regulated. In women with PCOS this delicate balance is disturbed by the presence of too many androgens. So how do they get there? The first theory is that the rhythm of reproductive hormones from the hypothalamus and anterior pituitary are disturbed. Luteinizing hormone (LH) and follicle stimulating hormone (FSH) are increased, resulting in immature follicles which are not released (anovulation), and abnormal or no menstruation. This promotes androgen production in the ovaries as well as in fat tissue where excess estrogen is converted to testosterone. The second theory is that women with PCOS seem to have high levels of insulin in their blood indicating insulin resistance. These high insulin levels contribute to hormone dysregulation independently of the HPA axis, though it may be simultaneous. Insulin can stimulate the ovaries and adrenal glands to increase production of androgens, and can also have an effect on the hypothalamus. Insulin also reduces the amount of sex hormone binding globulin (SHBG,) resulting in more sex hormones exhibiting longer effects.

 

Insulin Management and PCOS

The strong correlation between insulin resistance and PCOS has directed alternative treatment with positive outcomes. Lifestyle considerations include fat loss through high intensity interval exercise - particularly if there is significant abdominal fat present, while dietary measures include some blood sugar management through consumption of high fibre, low glycemic index foods. New research has emerged to support the supplementation of key nutrients to mitigate the symptoms of PCOS:

 

The benefits of Inositol

Inositol is a carbohydrate compound and a “B-vitamin like”  nutrient. In nature, it is found in many foods including grains and citrus fruit. It is a key component of cellular membranes, sending signals between cells and even increasing how sensitive cell receptors are to various molecules. In recent years, research has uncovered the powerful effects of high doses of this nutrient on regulating the menstrual cycle, supporting the healthy functioning of the ovaries, balancing mood and regulating metabolic factors. In regards to PCOS treatment, researchers have found that 1-4g/day of inositol has been correlated with a statistically significant reduction in  blood sugar levels.

 

Mood

Inositol is a precursor to the key neuronal phospholipid phosphatidylinositol 4,5-bisphosphate (PIP2), which occupies a pivotal place in the phosphoinositide cycle. This cycle is essential to multiple brain signaling systems, delivering messages from a variety of hormones and neurotransmitters (brain messenger-molecules) from receptors on the nerve cell membrane into the heart of the cell.

A decade ago, scientists armed with an emerging understanding of the phosphoinositide cycle began studies of high-dose supplementation with inositol powder in people suffering with a variety of psychological disorders linked to abnormal phosphoinositide signaling. These trials have found inositol to be a safe, natural nutritional approach which delivers effective support for many mental conditions and states of mind - often providing highly effective results but without the side effects and potential for addiction posed by commonly available treatments.

 

Myo vs. D-Chiro Inositol

Both Myo and D-Chiro Inositol are isomers (different forms) of the inositol molecule.  Myo-inositol is the most abundant form of inositol in nature; whereas D-Chiro-inositol is synthesized by a reaction that converts Myo-inositol to D-Chiro-inositol.  Although they have similar names, they perform different functions in the body, making it imperative to sustain a unique ratio of both molecules.  Myo-inositol helps regulate hormones such as TSH, FSH and insulin-important components for thyroid, menstrual and metabolic function. Myo-inositol is also most abundant in the central nervous system, thus there is more research that supports this form for mood balancing. In the past, the D-chiro form of inositol was preferred for management of PCOS and blood sugar regulation. Studies show that D-Chiro-inositol improves glycogen synthesis, an important factor in promoting the muscular uptake of glucose which improves body fat composition.  Together, they have beneficial effects on insulin activity, androgen levels, ovarian function, metabolic parameters and mood balance.  A 2013 study concluded that combined doses of Myo- and D-chiro-inositol are more effective at improving embryo quality and ovarian function than Myo-inositol alone, due to the synergy in both molecules working together.

 

Folic Acid

To prevent neural tube defects in infants, doctors now advise all of their female, reproductive age patients to use folic acid supplements in case of pregnancy. Folic acid, or vitamin B9, is an important nutrient for regulating the body’s genetic material, which is critical during pregnancy, but it does more than just that. Folic acid is required for energy production, proper brain and mental function; maintaining healthy red blood cells and reducing homocysteine. Homocysteine is a dangerous byproduct of metabolism created by the body; it is associated with cardiovascular, bone and neurological disorders. Studies show that women with endocrine and reproductive disorders are commonly deficient in folate and have higher homocysteine levels.  Supplementing with folate improves homocysteine, insulin and cholesterol levels in these women.  Due to these results, researchers have suggested that these women are deficient in 5-methylenetetrahydrofolate reductase, the enzyme responsible for converting folate to its active form 5-methyltetrahydrofolate (5-MTHF), the compound which can be used by the body.  AOR’s Advanced PCOS relief is formulated with folic acid in its already bioactive, 5-MTHF form for better efficacy. 

 

Advanced PCOS Relief represents a natural, safe and comprehensive approach to supporting both the symptomatic and biochemical aspects of the endocrine system. Advanced PCOS Relief is formulated with a synergistic combination of both Myo- and D-chiro-inositol along with the active form of folic acid. Advanced PCOS Relief is manufactured with a unique, patented vegan softgel technology, making it convenient, absorbable and suitable for various dietary preferences.

Inositol and Blood Sugar management:

The New England Journal of medicine published a paper in 1999 demonstrating the benefits of D-chiro-inositol on serum free testosterone, insulin sensitivity, systolic and diastolic blood pressure.

 

Benefits of combined Myo and D-chiro inositol for treatment of PCOS

A study was conducted in 2012 in which 50 overweight women with PCOS were treated with myo-inositol or a combination of myo- and d-chiro inositol. It was found that a combined administration of 40:1 myo-inositol:d-chiro inositol was most effective in reducing metabolic and clinical parameters.

Another study conducted in 2013 examined IVF outcomes in women with PCOS. Researchers examined the oocyte and embryo quality, as well as pregnancy rates. They found that the combined therapy approach yielded more significant results than treatment with d-chiro-inositol alone.

 

Myo-inositol softgel versus powder

In 2012, Italian scientists examined the difference in bioavailability between powder forms and softgel forms of myo-inositol. They found that the softgel form resulted in similar pharmacokinetics as three times that of the powdered dose.

 

Inositol and mood

Research has found 12-18 grams/day of inositol to be effective for depression, panic disorders and obsessive-compulsive disorder, among other mood disorders. While this is the evidence-based dosage for mood disorders, some people may still derive benefits from lower dosages.

 

Artini, P.G., Di Berardino, O.M., Papini, F., Genazzani, A.D., Simi, G., Ruggiero, M., & Cela, V. Endocrine and clinical effects of myo-inositol administration in polycystic ovary syndrome: A randomized study. Gynecological Endocrinology. 2013; 29(4):375-379.

Benjamin, J., et al. Double blind placebo controlled crossover trial of inositol treatment of panic disorders. Am J Psychiatry. 1995; 52:1084-1086

Carlomagno, G.,  De Grazia, S., Unfer, V., & Fedele Manna. Myo-inositol in a new pharmaceutical form: a step forward to a broader clinical use. Expert Opin. Drug Deliv. 2012; 9(3):267-271.

Colazingari , S., Treglia, M., Najjar, R., & Bevilacqua, A. The combined therapy myo-inositol plus D-chiro-inositol, rather than D-chiro-inositol, is able to improve IVF outcomes: results from a randomized controlled trial. Arch Gynecol Obstet. 2013; 288:1405–1411.DOI 10.1007/s00404-013-2855-3.

Ferri, F., Polycystic Ovary Syndrome. Ferri’s Clinical Advisor. 2016. 981-982 (3). Philadelphia: Mosby.

Fux, M., et al. Inositol treatment of obsessive-compulsive disorder. Am J Psychiatry. 1996; 53: 1219-1221

Genazzani, A., et al. Differential Insulin Response to Myo-Inositol Administration in Obese Polycystic Ovary Syndrome Patients. Gynecol Endocrinol. 2012; 28(120):969-973.

Huang, G., et al. Clinical Update on Screening, Diagnosis and Management of Metabolic Disorders and Cardiovascular Risk Factors Associated with Polycystic Ovary Syndrome. Curr Opin Endocrinol Diabetes Obes. 2012; 19(6): 512-519.

Levine, J., et al. Double blind controlled trial of inositol treatment of depression. Am J Psychiatry. 1995; 152: 792-794.

Minozzi, M., Nordio, M., &Pajalich, R. The combined therapy myo-inositol plus D-Chiro-inositol, in a physiological ratio, reduces the cardiovascular risk by improving the lipid profile in PCOS patients. European Review for Medical and Pharmacological Sciences. 2013; 17: 537-540.

Nestler, J.E., Jakubowicz, D.J., Reamer, P., Gunn, R.D., &Allan, G. Ovulatory and metabolic effects of D-chiro-inositol in the polycystic ovary syndrome. N. Engl. J. Med. 1999; 340 (17); 1314-20. DOI: 10.1056/NEJM199904293401703.

Nordio, M., & Proietti, E. The Combined therapy with myo-inositol and D-Chiro-inositol reduces the risk of metabolic disease in PCOS overweight patients compared to myo-inositol supplementation alone. European Review for Medical and Pharmacological Sciences. 2012; 16: 575-581.

Thomson, R., et al. The Effect of a Hypocaloric Diet with and without Exercise Training on Body Composition, Cardiometabolic Risk Profile, and Reproductive Function in Overweight and Obese Women with Polycystic Ovary Syndrome. J Clin Endocrinol Metab. 2008; 93(9):3373-3380.

Unfer, V., et al. Effects of Myo-Inositol in Women with PCOS: A Systematic Review of Randomized Controlled trials. Gynecol Endocrinol. 2012; 28(7):509-515.

 

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