(Adult): Take 1 capsule twice daily on an empty stomach, not immediately before bedtime, or as directed by a qualified health care practitioner.
Helps Your Body Deal with Stress
Rhodiola rosea is an herb with a long history of use for helping the body to adapt to the stressors of life. Rhodiola has been listed in the national pharmacopoeias of France, Sweden, Denmark, and Russia as an adaptogen and overall "brain tonic". Adaptogens support the body’s ability to handle stress by balancing the levels of hormones and neurotransmitters normally associated with the stress response. Rhodiola is unique among adaptogens in that it has been clinically shown to increase energy reserves and reduce levels of the stress hormone, cortisol. Rhodiola has been found to improve mental performance during night-shift duty, helping reduce fatigue in shift workers as well as the average person suffering from general fatigue.
Rhodiola is the ideal herbal product for those who frequently experience stress, especially those who respond to stressors with a feeling of helplessness. It is especially helpful for shift workers or those with high-stress lifestyles.
Rhodiola is a powerful adaptogen which helps support focus, cognitive function, mental and physical stamina and helps relieve symptoms of mental fatigue related to stress. It has been traditionally used in Siberia for adaptation to the harsh climates on the tundra of north-central Asia.
|Amount Per Serving Amount: 2 Capsules|
|340 mg Rhodiola rosea extract (3% rosavin, 1% salidroside)|
|Non-medicinal ingredients: Capsule: hypromellose.|
AOR™ guarantees that all ingredients have been declared on the label. Contains no wheat, gluten, corn, nuts, peanuts, sesame seeds, sulphites, mustard, soy, dairy, eggs, fish, shellfish or any animal byproduct.
(Adult): Take 1 capsule twice daily on an empty stomach, not immediately before bedtime, or as directed by a qualified health care practitioner.
Consult a healthcare practitioner if you are pregnant, breastfeeding, if you are taking antidepressant medication, hormone replacement therapy (HRT) or birth control pills, if symptoms persist or worsen, or for use beyond 6 weeks. Do not use if you have bipolar spectrum disorder. May cause irritability and insomnia, in which case, discontinue use.
Rhodiola rosea root
The information and product descriptions appearing on this website are for information purposes only, and are not intended to provide or replace medical advice to individuals from a qualified health care professional. Consult with your physician if you have any health concerns, and before initiating any new diet, exercise, supplement, or other lifestyle changes.
Authentic Russian Rhodiola’s Roots
Rhodiola is authentic Russian Rhodiola rosea, an herb with a long history of use as an adaptogen and sexual tonic in the traditional medicine of Iceland, Norway, the Carpathian Mountains of the Ukraine, and above all in Siberia, for adaptation to the rigors of life on the tundra of North-central Asia. Dioscorides, the father of medical botany, provides the earliest documented medicinal use of this botanical in De Materia Medica, a phytomedicinal text which formed the basis of Western pharmaceutical and herbal writing for the next 1500 years. In more recent times, Rhodiola preparations have been listed in the national pharmacopoeias of France, Sweden, Denmark, and the former USSR, as an adaptogen and “brain tonic.” In the nations of the former Soviet Union, Rhodiola is traditionally prepared in the form of a tincture called “nastojka”, decocted from fresh Rhodiola roots by soaking the roots in 40% alcohol for one week.
Rigorous testing of Rhodiola’s adaptogenic properties began in the former Soviet Union in the mid-60s, and has continued to this day. Four decades of animal studies and controlled clinical trials in humans clearly demonstrate that Rhodiola extract is a true adaptogenic botanical.
Adaptogens Help You Adapt
As a classic adaptogen, Rhodiola extracts both steel the organism against the eventuality of stressors, and prevent an overshoot into burnout when those stressors are endured. This can be seen in the botanical’s simultaneous bolstering of the baseline levels of adaptive neurotransmitters and hormones that are typically increased in response to adaptation to the rigors of endurance training and in the prevention of overactivation of those same pathways when the organism is in a stressful environment.
Some of Rhodiola’s Adaptogenic Activities
As an example of the adaptive, balancing effect of Rhodiola, its key component salidroside has been found to prevent excessive blood sugar levels after an injection of adrenaline (which normally causes the body to pump out more glucose) and to prevent blood sugar levels from falling too low after an injection of insulin. Rhodiola rosea‘s reputation as an adaptogen includes the ability to stimulate the nervous system, decrease depression, reduce insomnia, enhance work performance, eliminate fatigue, and prevent high altitude sickness. It is also claimed to function as an antidepressant, antianxiolytic, to protect the cardiovascular system, to enhance the central nervous system and to fight cancer.
It’s How You Feel
People who have tried this botanical report that they feel better on Rhodiola. The effect is described in terms of a continuous sensation of physical and mental relief from stress, and anecdotally appears to be most pronounced in people who typically respond to stress with anger or sensations of helplessness. While most stimulants of the central nervous system such as caffeine and amphetamines create a temporary effect that is lessened with repeated intakes, Rhodioa rosea was found to maintain its effects despite repeated intakes.
Rhodiola is one of the most effective and clinically studied adaptogenic herbs on the market. Some of the other common adaptogenic supplements available are ginseng, maca, schisandra and ashwagandha.
AOR’s Rhodiola provides a concentrated form of pure Rhodiola rosea root extract in an effective dose.
Once clinical trial found that in burn-out patients suffering from fatigue, Rhodiola reduced their cortisol (the stress hormone) levels upon awakening and improved their mental concentration, a capacity that is affected during burn-out.
Rat studies have also found that Rhodiola rosea could block the growth of tumors, decrease metastasis, and extend survival times. It also enhanced the effects of the antitumor drug cyclophosphamide.
Soviet scientists discovered a generation ago that Rhodiola allows experimental animals to use their body’s glycogen energy reserves more sparingly under forced exercise, and to replenish those reserves (and reserves of the crucial high-energy compound creatine phosphate) more quickly afterwards. These properties doubtless contribute to Rhodiola’s ability to extend animals’ endurance during forced swimming or clinging to a rod to avoid falling. To make sure that Rhodiola’s effects on physical performance was an adaptogenic effect, and not caused by flooding the body with steroids, scientists looked for the kind of hyper-masculinization you see in steroid freaks at the gym: no such signs were found.
Accordingly, Rhodiola extracts improve the organism’s capacity to stand up against a wide variety of stressors, including heat shock, heavy metal exposure, free radical assault, high altitude, liver-damaging chemicals, and exhaustive exercise. When eggs from freshwater snails were incubated with Rhodiola rosea, they had a survival rate of 90% when exposed to heat shock, compared to only 9% for eggs that were not exposed to Rhodiola.
Another example is Rhodiola’s ability to protect the heart from stress. When lab animals are subjected to extreme cold or to massive doses of the stress hormone adrenaline, the regular, controlled beating of their hearts is disrupted and the oxygen supply is temporarily cut off. But Rhodiola supplements prevent arrhythmia, reduce the damage to the muscle cells of the heart, and balance the overflow of stress neurotransmitters normally associated with these stressors.
Studies suggest that Rhodiola can help prevent symptoms associated with intense physical or mental strain such as a decline in work performance, sleep difficulties, poor appetite, irritability, hypertension, headaches and fatigue. In rats, Rhodiola rosea was found to benefit learning and memory. In a human clinical trial, a Rhodiola rosea extract along with a combination of vitamins and minerals was given to 120 adults with physical and cognitive deficiencies in a 12 week drug monitoring study. There was a significant improvement in these deficiencies, with observed improvements in symptoms such as exhaustion, decreased motivation, daytime sleepiness, sleep disturbances, concentration deficiencies, forgetfulness, susceptibility to stress and irritability. This is likely due to Rhodiola’s ability to influence the levels of several neurotransmitters in the brain.
Animal studies have given us some clues to the neurochemical basis of these effects: Rhodiola has well-documented effects on the metabolism of a variety of neurotransmitters. For instance, Rhodiola enhances the transport of the serotonin precursors tryptophan and 5-hydroxytryptophan (5-HTP) across the blood-brain barrier, and decreases the action of the serotonin-degrading catechol-O-methyltransferase (COMT) enzyme. It also boosts brain levels of dopamine, acetylcholine, and norepinephrine, all of which are key neurotransmitters targeted by major classes of antidepressant drugs. Rhodiola also appears to influence the synthesis, levels, and/or activity of endorphins and enkephalins, since blocking the receptors for some of these “feel-good” peptides negates some of Rhodiola’s effects.
The Importance of Full Standardization
Earlier research identified salidroside (and its free form, p-tyrosol) as a key active ingredient in Rhodiola, and many clinical trials still use salidroside as the sole active for standardization of their Rhodiola botanicals. More recently, studies have focused on the effects of rosavin. Some Rhodiola species found in China and elsewhere contain salidroside but not rosavin, the most characteristic active ingredient of true Rhodiola rosea. On the other hand, many products fail to standardize for the salidroside content, despite the extensive documentation of its adaptogenic effects. A properly-standardized Rhodiola extract will contain at least 3% rosavins and 1% salidroside; p-tyrosol will also be present in small amounts.
Bocharova OA, Matveev BP, Baryshnikov AIu, Figurin KM, Serebriakova RV, Bodrova NB. The effect of a Rhodiola rosea extract on the incidence of recurrences of a superficial bladder cancer (experimental clinical research) Urol Nefrol (Mosk) 1995 Mar-Apr; (2): 46-7.
Brekhman II, Dardymov IV. New substances of plant origin, which increase nonspecific resistance. Ann Rev Pharm.1969; 9: 419-30.
Bystritsky A, Kerwin L, Feusner JD. A pilot study of Rhodiola rosea (Rhodax) for generalized anxiety disorder (GAD). J Altern Complement Med. 2008 Mar;14(2):175-80.
De Bock K, Eijnde BO, Ramaekers M and Hespel P. Acute rhodiola rosea intake can improve endurance exercise performance. International Journal of Sport Nutrition and Exercise Metabolism. 2004;14:298-307.
Fintelmann V, Gruenwald J. Efficacy and tolerability of a rhodiola rosea extract in adults with physical and cognitive deficiencies. Advances in Therapy 2007;24(4):929-939
Kelly GS. Rhodiola Rosea: A possible plant adaptogen. Altern Med Rev 2001;6(3):293-302.
Maslova LV, Kondrat’ev BIu, Maslov LN, Lishmanov IuB. The cardioprotective and antiadrenergic activity of an extract of Rhodiola rosea in stress. Eksp Klin Farmakol 1994 Nov-Dec; 57(6): 61-3.
Effects of chronic Rhodiola Rosea supplementation on sport performance and antioxidant capacity in trained male: preliminary results.
J Sports Med Phys Fitness. 2010 Mar;50(1):57-63.
Parisi A, Tranchita E, Duranti G, Ciminelli E, Quaranta F, Ceci R, Cerulli C, Borrione P, Sabatini S.
AIM: Rhodiola Rosea, is an adaptogen plant which has been reported to promote fatty acids utilisation, to ameliorate antioxidant function, and to improve body resistance to physical strenuous efforts. The purpose of the present study was to investigate the effects on physical performance as well as on the redox status of a chronic Rhodiola Rosea supplementation in a group of competitive athletes during endurance exercise.
METHODS: Following a chronic supplementation with Rhodiola Rosea for 4 weeks, 14 trained male athletes underwent a cardio-pulmonary exhaustion test and blood samples to evaluate their antioxidant status and other biochemical parameters. These data were compared with those coming from the same athletes after an intake of placebo.
RESULTS: The evaluation of physical performance parameters showed that HR Max, Borg Scale level, VO(2) max and duration of the test were essentially unaffected by Rhodiola Rosea assumption. On the contrary, Rhodiola Rosea intake reduced, in a statistically significative manner, plasma free fatty acids levels. No effect on blood glucose was found. Blood antioxidant status and inflammatory parameters resulted unaffected by Rhodiola Rosea supplementation. Blood lactate and plasma creatine kinase levels were found significantly lower (P CONCLUSION: Chronic Rhodiola Rosea supplementation is able to reduce both lactate levels and parameters of skeletal muscle damage after an exhaustive exercise session. Moreover this supplementation seems to ameliorate fatty acid consumption. Taken together those observation confirm that Rhodiola Rosea may increase the adaptogen ability to physical exercise.
A randomised, double-blind, placebo-controlled, parallel-group study of the standardised extract shr-5 of the roots of Rhodiola rosea in the treatment of subjects with stress-related fatigue.
Planta Med. 2009 Feb;75(2):105-12.
Olsson EM, von Schéele B, Panossian AG.
The aim of the study was to assess the efficacy of the standardised extract SHR-5 of roots of Rhodiola Rosea L. in the treatment of individuals suffering from stress-related fatigue. The phase III clinical trial took the form of a randomised, double-blind, placebo-controlled study with parallel groups. Participants, males and females aged between 20 and 55 years, were selected according to the Swedish National Board of Health and Welfare diagnostic criteria for fatigue syndrome. A total of 60 individuals were randomised into two groups, one ( N = 30) of which received four tablets daily of SHR-5 extract (576 mg extract/day), while a second ( N = 30) received four placebo tablets daily. The effects of the extract with respect to quality of life (SF-36 questionnaire), symptoms of fatigue (Pines’ burnout scale), depression (Montgomery -Asberg depression rating scale – MADRS), attention (Conners’ computerised continuous performance test II – CCPT II), and saliva cortisol response to awakening were assessed on day 1 and after 28 days of medication. Data were analysed by between-within analyses of variance. No serious side effects that could be attributed to the extract were reported. Significant post-treatment improvements were observed for both groups (placebo effect) in Pines’ burnout scale, mental health (SF-36), and MADRS and in several CCPT II indices of attention, namely, omissions, commissions, and Hit RT SE. When the two groups were compared, however, significant effects of the SHR-5 extract in comparison with the placebo were observed in Pines’ burnout scale and the CCPT II indices omissions, Hit RT SE, and variability. Pre- VERSUS post-treatment cortisol responses to awakening stress were significantly different in the treatment group compared with the control group. It is concluded that repeated administration of R. ROSEA extract SHR-5 exerts an anti-fatigue effect that increases mental performance, particularly the ability to concentrate, and decreases cortisol response to awakening stress in burnout patients with fatigue syndrome.
Acute Rhodiola rosea intake can improve endurance exercise performance.
Int J Sport Nutr Exerc Metab. 2004 Jun;14(3):298-307.
De Bock K, Eijnde BO, Ramaekers M, Hespel P.
PURPOSE: The purpose of this study was to investigate the effect of acute and 4-week Rhodiola rosea intake on physical capacity, muscle strength, speed of limb movement, reaction time, and attention.
METHODS: PHASE I: A double blind placebo-controlled randomized study (n= 24) was performed, consisting of 2 sessions (2 days per session). Day 1: One hour after acute Rhodiola rosea intake (R, 200-mg Rhodiola rosea extract containing 3% rosavin 1% salidroside plus 500 mg starch) or placebo (P, 700 mg starch) speed of limb movement (plate tapping test), aural and visual reaction time, and the ability to sustain attention (Fepsy Vigilance test) were assessed. Day 2: Following the same intake procedure as on day 1, maximal isometric knee-extension torque and endurance exercise capacity were tested. Following a 5-day washout period, the experimental procedure was repeated, with the treatment regimens being switched between groups (session 2). PHASE II: A double blind placebo-controlled study (n = 12) was performed. Subjects underwent sessions 3 and 4, identical to Phase I, separated by a 4-week R/P intake, during which subjects ingested 200 mg R/P per day.
RESULTS: PHASE I: Compared with P, acute R intake in Phase I increased (p CONCLUSION: Acute Rhodiola rosea intake can improve endurance exercise capacity in young healthy volunteers. This response was not altered by prior daily 4-week Rhodiola intake.
A randomized trial of two different doses of a SHR-5 Rhodiola rosea extract versus placebo and control of capacity for mental work.
Phytomedicine. 2003 Mar;10(2-3):95-105.
Shevtsov VA, Zholus BI, Shervarly VI, Vol’skij VB, Korovin YP, Khristich MP, Roslyakova NA, Wikman G.
A randomized, double-blind, placebo-controlled, parallel-group clinical study with an extra non-treatment group was performed to measure the effect of a single dose of standardized SHR-5 Rhodiola rosea extract on capacity for mental work against a background of fatigue and stress. An additional objective was to investigate a possible difference between two doses, one dose being chosen as the standard mean dose in accordance with well-established medicinal use as a psychostimulant/adaptogen, the other dose being 50% higher. Some physiological parameters, e.g. pulse rate, systolic and diastolic blood pressure, were also measured. The study was carried out on a highly uniform population comprising 161 cadets aged from 19 to 21 years. All groups were found to have very similar initial data, with no significant difference with regard to any parameter. The study showed a pronounced antifatigue effect reflected in an antifatigue index defined as a ratio called AFI. The verum groups had AFI mean values of 1.0385 and 1.0195, 2 and 3 capsules respectively, whilst the figure for the placebo group was 0.9046. This was statistically highly significant (p < 0.001) for both doses (verum groups), whilst no significant difference between the two dosage groups was observed. There was a possible trend in favour of the lower dose in the psychometric tests. No such trend was found in the physiological tests.