AOR^TM certifie qu'aucun ingrédient non mentionné sur l'étiquette n'a été ajouté au produit. Ne contient ni blé, ni gluten, ni maïs, ni noix, ni produits laitiers, ni soja, ni oeufs, ni poissons, ni mollusques ou crustacés.

Posologie Adulte: Prendre deux capsules deux fois par jour sans nourriture pour une mois, puis deux capsules par jour, ou selon les directives d'un conseiller qualifié de la santé.

Mise en Garde: Aucune

Applications: Soulagement des symptômes de la ménopause et de l'andropause, Syndrome prémenstruel, Performance sportive, Libido

Source: Racine de Lepidum meyenii

Copyright © 2005, Advanced Orthomolecular Research

La Maca (Lepidium peruvium chacon) est une plante indigène du Pérou dont les raciness sont mangées comme un légume. Avec une teneur élevée en minéraux, la Maca contient quatre alcaloïdes, les macainas. Les expériences cliniques suggèrent que ces alcaloïdes nourrissent les glandes endocriniennes d'une façon adaptogénique, c'est-à-dire, qu'elles équilibrent les hormones stéroïdes principales telles que l'oestrogène, la progestérone et la testostérone. La Maca peut créer des effets spécifiques à la condition de l'individu, élevant les niveaux d'hormones inadéquats tout en abaissant les niveaux élevés d'hormones.

Les professionnels de la santé qui utilisent la Maca dans leur pratique rapportent que la Maca aide à améliorer la fonction sexuelle masculine et que cette racine est utile pour la normalisation d'hormones à la ménopause, ainsi que pour traiter les symptoms prémenstruels, pour combattre le stress, pour améliorer les niveaux d'énergie et pour aider à maintenir des niveaux sains de glucose dans le sang.
Une étude avec des rats de laboratoire a démontré que les animaux recevant de la poudre de racine de Maca ou un extrait de macainas ont une plus grande maturation de follicule (femelles) ou une production plus élevée de sperme (mâles) après trois jours de supplémentation. Une étude de laboratoire plus récente prouve également que la Maca active et protège le facteur de croissance analogue à l'insuline (IGF-1) chez les cellules de cartilage humaines.

References

i. Gonzales GF, Cordova A, Vega K, Chung A, Villena A, Gonez C, Castillo S. "Effect of Lepidium meyenii (MACA) on sexual desire and its absent relationship with serum testosterone levels in adult healthy men." Andrologia 2002 Dec; 34(6): 367-72.

ii. Cicero AF, Bandieri E, Arletti R. "Lepidium meyenii Walp. improves sexual behaviour in male rats independently from its action on spontaneous locomotor activity." J Ethnopharmacol 2001 May; 75(2-3): 225-9.

iii. Zheng BL, He K, Kim CH, Rogers L, Shao Y, Huang ZY, Lu Y, Yan SJ, Qien LC, Zheng QY. "Effect of a lipidic extract from lepidium meyenii on sexual behavior in mice and rats." Urology 2000 Apr; 55(4): 598-602.

iv. Cicero AF, Piacente S, Plaza A, Sala E, Arletti R, Pizza C. "Hexanic Maca extract improves rat sexual performance more effectively than methanolic and chloroformic Maca extracts." Andrologia 2002 Jun; 34(3): 177-9.

v. Chacon de Popvici (1961), "Estudio fitoquimico de Lepidium meyenii Walp." Thesis, Universidad Nacional Mayor de San Marcos: 43.

ii. Dilman VM. (1971), "Age-associated elevation of hypothalamic, threshold to feedback control, and its role in development, ageing, and disease." Lancet. 1971 Jun 12; 1(7711): 1211-9.

Copyright © 2005, Advanced Orthomolecular Research

Rats were treated with 0, 8, 16 and 24 mg/kg of lead acetate (LA) (i.p.) for 35 days with or without Maca. Maca was co-administrated orally from day 18 to day 35. The lengths of stages of the seminiferous epithelium were assessed by transillumination. Also, sex organ weights, testicular and epididymal sperm count, sperm motility, daily sperm production, sperm transit rate and serum testosterone levels were measured. Lead acetate treatment resulted in a dose-response reduction of lengths of stages VIII and IX-XI, and serum testosterone levels. However, rats treated with 8 and 16 mg/kg but not 24 mg/kg of lead acetate showed a low number of testicular spermatids, low daily sperm production (DSP) and low epididymal sperm count. Administration of Maca to rats treated with lead acetate resulted in higher lengths of stages VIII and IX-XI with respect to lead acetate-treated rats. Moreover, treatment with Maca to lead acetate-treated rats resulted in lengths of stages VIII and IX-XI similar to the control group. Maca administration also reduced the deleterious effect on DSP caused by lead acetate treatment. Maca prevented LA-induced spermatogenic disruption in rats and it may become in a potential treatment of male infertility associated with lead exposure.

Effect of three different cultivars of Lepidium meyenii (Maca) on learning and depression in ovariectomized mice.
BMC Complement Altern Med. 2006 Jun 23;6:23.
Rubio J, Caldas M, Dávila S, Gasco M, Gonzales GF.

BACKGROUND: Lepidium meyenii Walp. (Brassicaceae), known as Maca, is a Peruvian hypocotyl growing exclusively between 4000 and 4500 m altitude in the central Peruvian Andes, particularly in Junin plateau and is used traditionally to enhance fertility. Maca is a cultivated plant and different cultivars are described according to the color of the hypocotyls.
METHODS: The study aimed to elucidate the effect of Yellow, Red and Black Maca on cognitive function and depression in ovariectomized (OVX) mice. In all experiments OVX mice were treated during 21 days and divided in four groups: control group, Yellow Maca, Red Maca and Black Maca. Latent learning was assessed using the water finding task and the antidepressant activity of the three varieties of Maca was evaluated using the forced swimming test. Animals were sacrificed at the end of each treatment and the uterus were excised and weighed.
RESULTS: Black Maca was the variety that showed the best response in the water finding task, particularly in the trained mice. The three varieties were effective to reduce finding latency in non trained and trained mice (P < 0.05). In the force swimming test, all varieties assessed reduced the time of immobility and increased uterine weight in OVX mice.
CONCLUSION: Black Maca appeared to have more beneficial effects on latent learning in OVX mice; meanwhile, all varieties of Maca showed antidepressant activity.

Medicinal plants from Peru: a review of plants as potential agents against cancer.
Anticancer Agents Med Chem. 2006 Sep;6(5):429-44.
Gonzales GF, Valerio LG.

Natural products have played a significant role in drug discovery and development especially for agents against cancer and infectious disease. An analysis of new and approved drugs for cancer by the United States Food and Drug Administration over the period of 1981-2002 showed that 62% of these cancer drugs were of natural origin. Natural compounds possess highly diverse and complex molecular structures compared to small molecule synthetic drugs and often provide highly specific biological activities likely derived from the rigidity and high number of chiral centers. Ethnotraditional use of plant-derived natural products has been a major source for discovery of potential medicinal agents. A number of native Andean and Amazonian medicines of plant origin are used as traditional medicine in Peru to treat different diseases. Of particular interest in this mini-review are three plant materials endemic to Peru with the common names of Cat's claw (Uncaria tomentosa), Maca (Lepidium meyenii), and Dragon's blood (Croton lechleri) each having been scientifically investigated for a wide range of therapeutic uses including as specific anti-cancer agents as originally discovered from the long history of traditional usage and anecdotal information by local population groups in South America. Against this background, we present an evidence-based analysis of the chemistry, biological properties, and anti-tumor activities for these three plant materials. In addition, this review will discuss areas requiring future study and the inherent limitations in their experimental use as anti-cancer agents.

Effect of Lepidium meyenii (MACA) on sexual desire and its absentrelationship with serum testosterone levels in adult healthy men.
Andrologia 2002 Dec; 34(6): 367-72.
Gonzales GF, Cordova A, Vega K, Chung A, Villena A, Gonez C, Castillo S.

This study was a 12-week double blind placebo-controlled, randomized, parallel trial in which active treatment with different doses of Maca Gelatinizada was compared with placebo. The study aimed to demonstrate if effect of Maca on subjective report of sexual desire was because of effect on mood or serum testosterone levels. Men aged 21-56 years received Maca in one of two doses: 1500 mg or 3000 mg or placebo. Self-perception on sexual desire, score for Hamilton test for depression, and Hamilton test for anxiety were measured at 4, 8 and 12 weeks of treatment. An improvement in sexual desire was observed with Maca since 8 weeks of treatment. Serum testosterone and oestradiol levels were not different in men treated with Maca and in those treated with placebo (P:NS). Logistic regression analysis showed that Maca has an independent effect on sexual desire at 8 and 12 weeks of treatment, and this effect is not because of changes in either Hamilton scores for depression or anxiety or serum testosterone and oestradiol levels. In conclusion, treatment with Maca improved sexual desire.

Lepidium meyenii Walp. improves sexual behaviour in male rats independently from its action on spontaneous locomotor activity.
J Ethnopharmacol 2001 May; 75(2-3): 225-9.
Cicero AF, Bandieri E, Arletti R.

Lepidium meyenii Walpers (Maca) is traditionally employed in the Andean region for its supposed properties to improve energy and fertility. The aim of this study was to evaluate the effect of acute and chronic Maca pulverised root oral administration on rat sexual behaviour. Sixty male sexually experienced rats (20 group) were daily treated for 15 days with Maca 15 mg kg(-1), Maca 75 mg kg(-1) or saline 0.5 ml kg(-1). The following sexual performance parameters were evaluated at first and last day of treatment: 1st mount (ML), 1st intromission (IL), ejaculation (EL) and postejaculatory (PEL) latencies, intercopulatory interval (ICI) and copulatory efficacy (CE). An activity cage test was carried out to evaluate if Maca-induced locomotion changes could indirectly improve rat sexual performances. It was observed that both lower and higher Maca doses acutely decreased ML, IL and ICI in a significant way (P < 0.05), while only the 75 mg kg(-1) dose decreased the PEL (T = 29, P < 0.05). This effect seems to be the only one dose-dependent. After 15 days of treatment, both doses are able tosignificantly decrease ML, IL, EL and PEL, while the 75 mg kg(-1) dose decreased the ICI (T = 40, P < 0.05) too. IL, EL and PEL variations seem to be dose-related after chronic treatment. Moreover, chronic Maca treatment induced an apparently not dose-related increase in rat locomotion, during the second 10-min period of observation in the activity cage. The late in Maca-induced locomotion modification excludes that improvement of tested sexual performance parameters is related to an increase in rat aspecific activity. Thus, it was concluded that both acute and chronic Maca oral administration significantly improve sexual performance parameters in male rats.

Effect of a lipidic extract from lepidium meyenii on sexual behavior in mice and rats.
Urology 2000 Apr; 55(4): 598-602.
Zheng BL, He K, Kim CH, Rogers L, Shao Y, Huang ZY, Lu Y, Yan SJ, Qien LC, Zheng QY.

OBJECTIVES: To determine the effect of oral administration of a purified lipidic extract from Lepidium meyenii (MacaPure M-01 and M-02) on the number of complete intromissions and mating in normal mice, and on the latent period of erection (LPE) in rats with erectile dysfunction.
METHODS: Mice and rats were randomly divided into several experimental and control groups. A 10% ethanol suspension of M-01 and M-02 was orally administered for 22 days to the experimental groups according to the dosage specified by the experimental design. On day 22, 30 minutes after the dose was administered to the male mice, 2 virgin female mice were placed with 1 male mouse. The number of complete intromissions of each male mouse in 3 hours was recorded. In an assessment of 1 day of mating, each male mouse was cohabited with 5 estrous female mice overnight. The number of sperm-positive females was recorded. The LPE was measured to assess the sexual function in rats with erectile dysfunction. By using a YSD-4G multifunction instrument, an electric pulse at 20 V was applied to stimulate the rat's penis, and the duration from the start of the stimulus to full erection was measured in seconds as the LPE.
RESULTS: In the normal male mice, the number of complete intromissions during the 3-hour period was 16.33 +/- 1.78, 46.67 +/- 2.39, and 67.01 +/- 2.55 for the control group, M-01 group, and M-02 group, respectively. In the assessment of mating, the number of sperm-positive females increased from 0.6 +/- 0.7 in the control group to 1.5 +/- 0.5 in the M-01 experimental group. The LPE of male rats with erectile dysfunction was 112 +/- 13 seconds with a regular diet (control group). The oral administration of M-01 at a dose of 180 or 1800 mg/kg body weight and M-02 at a dose of 45, 180, or 1800 mg/kg body weight reduced the LPE to 54 +/- 12 seconds, 54 +/- 13 seconds, 71 +/- 12 seconds, 73 +/- 12 seconds, and 41 +/- 13 seconds, respectively. The LPE of the surgical rats treated with M-01 at the lowest dose (45 mg/kg) was 121 +/- 12 seconds; thus, the change was not significant.
CONCLUSIONS: Oral administration of M-01 and M-02 enhanced the sexual function of the mice and rats, as evidenced by an increase in the number of complete intromissions and the number of sperm positive females in normal mice, and a decrease in the LPE in male rats with erectile dysfunction. The present study reveals for the first time an aphrodisiac activity of L. meyenii, an Andean Mountain herb.

Hexanic Maca extract improves rat sexual performance more effectively than methanolic and chloroformic Maca extracts.
Andrologia 2002 Jun; 34(3): 177-9.
Cicero AF, Piacente S, Plaza A, Sala E, Arletti R, Pizza C.

Lepidium meyenii (Maca) is traditionally employed in the Andean region for its supposed properties in improving fertility. The aim of this study was to determine the effect of subacute oral administration of hexanic, methanolic and chloroformic extracts of Maca root on sexual performance in inexperienced male rats. The following sexual performance parameters were evaluated: 1st mount, 1st intromission, ejaculation and post-ejaculatory latencies, intercopulatory interval and copulatory efficacy. All the tested fractions significantly decreased intromission latency and intercopulatory interval and increased intromission frequency and copulatory efficacy (P < 0.05) as compared to controls. Hexanic and methanolic extracts were able to increase mount frequency (MF), while only hexanic fraction significantly improved mount latency (ML) (P=0.038). Globally, only the hexanic fraction significantly improved the majority of the sexual parameters measured. Sub-acute oral administration of hexanic Maca extract improved sexual performance parameters in sexually inexperienced male rats most effectively.

Copyright © 2005, Advanced Orthomolecular Research