Hyaluronic acid (HA) is a compound that is found in high concentrations in the synovial fluid (the fluid that surrounds and cushions joints) and in the skin. Because of this, HA is a commonly used supplement to support both joint and skin health. However, HA is a fairly high-weight molecule and there is some debate over whether or not orally consumed HA is effectively absorbed into the blood stream and taken up by the tissues. A new study provides evidence that orally supplemented HA does in fact reach the skin and connective tissues.
In the study, radioactively labeled HA was given orally to rats and dogs, and the excretion and tissue distribution of the HA was then monitored. After 24 hours the skin, connective tissues and bones of the animals showed incorporation of the radioactive HA. Furthermore, when a different radioactively labeled compound was given, no accumulation in the tissues, bones or skin was observed.
HA is known to have a high affinity for connective tissues. This, along with the results of the study indicate that a certain amount of orally supplemented HA is, in fact, absorbed into the bloodstream and incorporated into connective tissues. This supports the use of HA supplements for joint and skin health, and is also consistent with other studies regarding HA. For example, in human studies, administration of HA has been associated with improvements in pain and joint function in osteoarthritis patients.
Balogh L et al. Absorption, uptake and tissue affinity of high-molecular-weight hyaluronan after oral administration in rats and dogs. Journal of Agricultural and Food Chemistry. 2008. 56: 10582-10593.
For more information see Hyaluronic Acid or Hyal Joint
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