Curcumin Active

Curcumin Active

Curcumin Active

The Most Absorbable Curcumin

  • A powerful compound derived from turmeric
  • Free from rapid breakdown by the body
  • Remains in the bloodstream for up to 24 hours
  • Fast acting and clinically proven for relief of severe pain and inflammation

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DISCUSSION: Curcuma longa is traditionally used in Herbal medicine as an anti-inflammatory to help relieve joint pain and provides antioxidants for the maintenance of good health.

NPN (what's this?)Product CodeSizePer CapsuleVegetarian
80034700 AOR0424760 Vegi-Caps133.3 mgVegetarian
Supplement Facts
Serving Size: 1 Capsule
Longvida® Optimized Curcumin* (from Curcuma longa root 25-30:1)133.3 mg
Non-medicinal ingredients: ascorbyl palmitate, microcrystalline cellulose, soy lecithin, stearic acid, maltodextrin, silicon dioxide. Capsule: hypromellose. *LONGVIDA® is a registered trademark of Verdure Sciences Inc. International patent pending.

AOR Guarantees: that no ingredients not listed on the label have been added to the product. Contains no wheat, gluten, nuts, peanuts, sesame seeds, sulphites, mustard, eggs, dairy, fish, shellfish or any animal byproduct.

Adult Dosage: Take 1 to 2 capsules daily, or as directed by a qualified health care practitioner.

Cautions: Consult a health care practitioner prior to use if you are taking antiplatelet medication or blood thinners, or if you have gallstones, a bile duct obstruction, stomach ulcers or excess stomach acid. Consult a health care practitioner if symptoms persist or worsen.

Pregnancy/Nursing: Consult a health care practitioner prior to use

Source:
100% pure curcumin from Longvida® Optimized Curcumin

Main Indications:

  • Inflammation
  • Pain
  • Antioxidant

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Disclaimer

The information and product descriptions appearing on this website are for information purposes only, and are not intended to provide or replace medical advice to individuals from a qualified health care professional. Consult with your physician if you have any health concerns, and before initiating any new diet, exercise, supplement, or other lifestyle changes.

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Research

Background Information

Do Not Confuse Turmeric Root with Curcumin!
Curcumin is a powerful anti-inflammatory derived from turmeric root. Turmeric root supplements absolutely do not offer the same benefits as those containing isolated curcumin. Curcumin is the most potent component of the turmeric root. Unfortunately, turmeric root contains less than 2% of curcumin making it ineffective for any health benefits. In addition, over 95% of all clinical studies have been conducted using isolated curcumin and NOT with the turmeric root. Even 750 mg of a 10:1 ratio extract of turmeric will deliver no more than 150 mg of the active curcumin. But given the poor bioavailability (the amount of the active compound that reaches the target site or site of action) of this compound, the amount you actually get is likely far less than that. Clinical studies suggest that the bioavailability is less than 5%, making even standard 95% curcumin formulations fairly ineffective.  As for a significantly weakened turmeric root formula? That becomes essentially useless!

Longvida®, a highly bioavailable form of curcumin, is the result of testing over two hundred formulations and has taken more than ten years to develop.  In a human bioavailability study involving patients, Longvida® curcumin was shown to be far more bioavailable than regular curcumin. This formulation was developed and patented by UCLA Medical School and is licensed exclusively to AOR.

Research

Bioavailability
Gota and colleagues did a safety and bioavailability study on healthy volunteers versus patients. Subjects were given doses between 400 and 1,200 mg of curcumin in solid lipid particle form (equivalent to 3 to 9 capsules of Curcumin Active). All doses showed significant absorption into the bloodstream over 8 hours with no adverse events.

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Market Trends

Numerous supplements on the market contain the curcumin extract of turmeric. However, many of these are poorly absorbed and offer little value in terms of therapeutic benefit due to their poor bioavailability.

New Technology – Better Products!
Over the last ten years a great deal of research has been done to develop formulations that improve the bioavailability of curcumin. The goal has been to deliver more of the active molecules to the body in a much lower daily dose; as few as one to three capsules per day. There have been a number of technologies developed, but the one that has provided the most compelling evidence is the Longvida® patented technology. It is so effective that other formulas won’t even compare themselves to Longvida® curcumin.

AOR Advantage

Longvida® curcumin was introduced to Canada exclusively by AOR in 2011. Curcumin Active is clinically proven to deliver several health benefits as a result of its high bioavailability and has the following advantages:

  • Clinically tested with results published in 2010 in the prestigious Journal of Agricultural and Food Chemistry. In the study, patients experienced few to no adverse effects and good tolerability of the equivalent of up to 9 capsules of Curcumin Active
  • Higher bioavailability compared to regular curcumin
  • Patented by the University of California
  • Recent human study showing positive effects on markers of health with just 80 mg of Longvida® curcumin per day for 1 month

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References

Begum et al. Curcumin Structure-Function, Bioavailability, and Efficacy in Models of Neuroinflammation and Alzheimer’s Disease.   J Pharmacol Exp Ther. 2008 Jul;326(1):196-208.

Dadhaniya P, Patel C, Muchhara J, Bhadja N, Mathuria N, Vachhani K, Soni MG. Chronic safety of Longvida. Food Chem Toxicol. 2011 May 6.

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Reviews

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FAQ

Q: Why does AOR still offer Curcumin-95 if Longvida® curcumin is better?

A: There will always be consumers who abide by holistic philosophy and prefer pure, natural extracts that have not been modified or altered by modern technologies.

Abstracts

Diverse effects of a low dose supplement of lipidated curcumin in healthy middle aged people.
Nutr J. 2012 Sep 26;11:79.
Disilvestro RA, Joseph E, Zhao S, Bomser J.

BACKGROUND: Curcumin extracts of turmeric are proposed to produce health benefits. To date, human intervention studies have focused mainly on people with existing health problems given high doses of poorly absorbed curcumin. The purpose of the current study was to check whether in healthy people, a low dose of a lipidated curcumin extract could alter wellness-related measures.
METHODS: The present study was conducted in healthy middle aged people (40-60 years old) with a low dose of curcumin (80 mg/day) in a lipidated form expected to have good absorption. Subjects were given either curcumin (N = 19) or placebo (N = 19) for 4 wk. Blood and saliva samples were taken before and after the 4 weeks and analyzed for a variety of blood and saliva measures relevant to health promotion.
RESULTS: Curcumin, but not placebo, produced the following statistically significant changes: lowering of plasma triglyceride values, lowering of salivary amylase levels, raising of salivary radical scavenging capacities, raising of plasma catalase activities, lowering of plasma beta amyloid protein concentrations, lowering of plasma sICAM readings, increased plasma myeloperoxidase without increased c-reactive protein levels, increased plasma nitric oxide, and decreased plasma alanine amino transferase activities.
CONCLUSION: Collectively, these results demonstrate that a low dose of a curcumin-lipid preparation can produce a variety of potentially health promoting effects in healthy middle aged people.

 

Safety and Pharmacokinetics of a Solid Lipid Curcumin Particle Formulation in Osteosarcoma Patients and Healthy Volunteers.
J Agric Food Chem. 2010; 58(4): 2095-2099.
Gota VS et al.

Curcumin is the lipid-soluble antioxidant compound obtained from the rhizome of Curcuma longa Linn, also known as turmeric. Curcumin targets multiple chemotherapeutic and inflammatory pathways and has demonstrated safety and tolerability in humans, supporting its potential as a therapeutic agent; however, the clinical literature lacks conclusive evidence supporting its use as a therapeutic agent due to its low bioavailability in humans. The purpose of this study was to quantify plasma levels of free curcumin after dosing of a solid lipid curcumin particle (SLCP) formulation versus unformulated curcumin in healthy volunteers and to determine its tolerability and dose−plasma concentration relationship in late-stage osteosarcoma patients. Doses of 2, 3, and 4 g of SLCP were evaluated in 11 patients with osteosarcoma. Plasma curcumin levels were measured using a validated high-performance liquid chromatography method. The limit of detection of the assay was 1 ng/mL of curcumin. In healthy subjects, the mean peak concentration of curcumin achieved from dosing 650 mg of SLCP was 22.43 ng/mL, whereas plasma curcumin from dosing an equal quantity of unformulated 95% curcuminoids extract was not detected. In both healthy individuals and osteosarcoma patients, high interindividual variability in pharmacokinetics and nonlinear dose dependency was observed, suggesting potentially complex absorption kinetics. Overall, good tolerability was noted in both healthy and osteosarcoma groups.