DISCUSSION: Curcumin Active™ is a high dose of the most absorbable optimized Curcuma longa formula that is free from rapid breakdown. It is traditionally used in herbal medicine as a powerful anti-inflammatory to help relieve severe joint pain and chronic inflammation.
|NPN (what's this?)||Product Code||Size||Per Capsule||Vegetarian|
|80034700||AOR04247||60 Vegi-Caps||133.3 mg||Vegetarian|
|Serving Size: 1 Capsule|
|Longvida® Optimized Curcumin* (from Curcuma longa root 25-30:1)||133.3 mg|
|Non-medicinal ingredients: ascorbyl palmitate, microcrystalline cellulose, soy lecithin, stearic acid, maltodextrin, silicon dioxide. Capsule: hypromellose. *LONGVIDA® is a registered trademark of Verdure Sciences Inc. International patent pending.|
AOR Guarantees: that no ingredients not listed on the label have been added to the product. Contains no wheat, gluten, nuts, peanuts, sesame seeds, sulphites, mustard, eggs, dairy, fish, shellfish or any animal byproduct.
Adult Dosage: Take 1 to 2 capsules daily, or as directed by a qualified health care practitioner.
Cautions: Consult a health care practitioner prior to use if you are taking antiplatelet medication or blood thinners, or if you have gallstones, a bile duct obstruction, stomach ulcers or excess stomach acid. Consult a health care practitioner if symptoms persist or worsen.
Pregnancy/Nursing: Consult a health care practitioner prior to use
100% pure curcumin from Longvida® Optimized Curcumin
The information and product descriptions appearing on this website are for information purposes only, and are not intended to provide or replace medical advice to individuals from a qualified health care professional. Consult with your physician if you have any health concerns, and before initiating any new diet, exercise, supplement, or other lifestyle changes.
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Free Yourself, with Free-Form Curcumin
Turmeric, Curcumin & Bioavailability – What’s All The Hype About?
Curcumin is well known for its anti-inflammatory and pain relieving properties, which are well supported by clinical studies. These studies have shown that curcumin is highly effective for improving joint mobility and for reducing stiffness, swelling and pain. However, until recently, very high doses of curcumin (over 8 g per day) have been required to achieve these results due to weak turmeric extracts that provide only 2% curcumin, and to the poor bioavailability of curcumin. Studies suggest that you need to take more than 8g of a regular 95% curcumin extract, which is somewhere between 10 and 20 capsules, before it becomes detectable in your blood! Taking this many capsules per day just to achieve an effective dose is highly inconvenient and costly. Furthermore, many products on the market are highly misleading, and may not be effective at all! Being aware of what is actually in each product and taking advantage of the latest advances in nutraceutical technology can help to ensure that you are getting the best possible curcumin supplement, and therefore the most effective relief from pain and inflammation.
Optimized Curcumin – Discover The Benefits
AOR’s Optimized Curcumin products are based on proven Solid Lipid Particle™ (SLP) technology and have the following advantages:
Optimized Curcumin consists of Solid Lipid Particles™ (SLP). This process involves a unique combination of highly purified lipids that coat the curcumin particles, which are also significantly reduced to 1 millionth of a millimeter in size. This combination is organized in such a way as to increase bioavailability and absorption, and remarkably avoid being rapidly broken down within the body. This unique formulation allows for each solid lipid curcumin particle to be taken up through the lymph system, as opposed to being absorbed directly into the circulation and broken down by the liver, therefore avoiding “first pass metabolism” or glucuronidation. The liver is the major organ responsible for metabolizing or breaking down substances. When something is ingested, it is either glucuronidated or sulphated by the liver. This process involves adding a glucuronide or sulphate group to the substance, making it extremely soluble. It is then carried to our kidneys and bowel and is ready for excretion. When curcumin is able to avoid this rapid breakdown, it retains its activity as free form curcumin. When it cannot, it is excreted out of the body rapidly, which is unfortunately the case with all other curcumins on the market. Finally, the tiny particle size and the lipid coating allows the curcumin to be taken up into the body’s cells quickly and put to use. This means that it delivers all of the health benefits of curcumin, including pain relief, reduced inflammation, antioxidant properties and other effects much faster and more effectively than any other curcumin product. Do you want to free yourself, with free form curcumin?
Try our Optimized Curcumin products today and start feeling the benefits of a true high-potency, free form curcumin supplement.
Curcumin Active is a high dose of fast-acting Optimized Curcumin. Optimized Curcumin was specially formulated to provide a solution to the curcumin conundrum of low bioavailability, poor absorption and rapid breakdown. Although bioavailability and absorption help determine effectiveness, the key lies within its ability to remain free. This free state of curcumin is achieved due to the formula’s ability to avoid being rapidly broken down within the body. Because free curcumin retains its “unbroken” form, it is then taken up through the blood stream where it is stable, concentrated, and retains maximum effectiveness for up to 24 hours, making it the most effective, absorbable curcumin available.
Curcumin Active works quickly to help relieve severe pain and conditions that stem from inflammation. Studies have shown curcumin is as effective as various common NSAIDs (non-steroidal anti-inflammatory drugs) in osteoarthritis sufferers, but much safer. Curcumin also helps reduce gastrointestinal inflammation and promotes healthy cell growth.
Curcumin is also known to be a powerful anti-microbial, anti-inflammatory, skin and wound healer, liver and gallbladder support, digestive aid, cardiovascular support and much more.
Those with severe osteoarthritis and joint pain, chronic inflammation and intestinal inflammatory disorders will highly benefit from Curcumin Active.
Gota and colleagues did a safety and bioavailability study on healthy volunteers versus patients. Subjects were given doses between 400 and 1,200 mg of curcumin in solid lipid particle form (equivalent to 1 to 2 capsules of Curcumin Active). All doses showed significant absorption into the bloodstream over 8 hours with no adverse events.
Longvida® Curcumin in Humans
A human trial on curcumin showed statistically significant effects on clinical endpoints in a healthy population. The fact that such a low dose (80 mg) was needed to achieve effects in only 30 days is an interesting and unique finding as well, and adds to the substantial amount of pharmacokinetic and pharmacodynamic data compiled on Longvida®. The results of the study suggest that curcumin can produce beneficial effects in people who are without immediate disease states. The study was conducted on 38 healthy middle aged people between the age of 40 and 60 who were either given a dose of 80 mg/day of Longvida® curcumin extract for four weeks or were a part of the 19 person placebo group. The study is particularly interesting because the relatively small dose of curcumin, from Longvida® which was used, exerted a variety of health promoting effects leading researchers to presume that a significant amount of the curcumin was absorbed, although not tested directly.
Blood sample readings collected from test subjects to assess nitric oxide and sICAM molecules were notably affected by the curcumin. Interestingly, other markers of inflammation and free radicals/toxic species that cause inflammation and damage to cells were also significantly lowered. Both direct and indirect antioxidant actions of curcumin were evident in the subjects; these findings are consistent with in vitro and animal studies used to measure increases in curcumin induced antioxidant enzyme activity.
Numerous supplements on the market contain the curcumin extract of turmeric. However, many of these are poorly absorbed and offer little value in terms of therapeutic benefit due to their poor bioavailability.
New Technology – Better Products!
Over the last ten years a great deal of research has been done to develop formulations that improve the bioavailability of curcumin. The goal has been to deliver more of the active molecules to the body in a much lower daily dose; as few as one to three capsules per day. There have been a number of technologies developed, but the one that has provided the most compelling evidence is the Longvida® patented technology. It is so effective that other formulas won’t even compare themselves to Longvida® curcumin.
Longvida® curcumin was introduced to Canada exclusively by AOR in 2011. Curcumin Active is clinically proven to deliver several health benefits as a result of its high bioavailability and has the following advantages:
Curcumin Active TM consists of solid lipid particles (SLP) which are tiny particles that have a protected layer that provides a phenomenal increase in stability, potency and effectiveness. Unlike regular curcumin that is easily broken down by stomach acids, Curcumin Fast Relief particles are resistant to acid breakdown. Even more important is the fact that these tiny particles are absorbed very rapidly. This means that they deliver all of the health benefits of curcumin, including pain relief, reduced inflammation, antioxidant properties and other effects much faster than any other curcumin product.
Try Curcumin Active TM today and start feeling the benefits of a real high-potency, high-bioavailability curcumin supplement.
Begum et al. Curcumin Structure-Function, Bioavailability, and Efficacy in Models of Neuroinflammation and Alzheimer’s Disease. J Pharmacol Exp Ther. 2008 Jul;326(1):196-208.
Dadhaniya P, Patel C, Muchhara J, Bhadja N, Mathuria N, Vachhani K, Soni MG. Chronic safety of Longvida. Food Chem Toxicol. 2011 May 6.
Disilvestro RA, Joseph E, Zhao S, Bomser J. Diverse effects of a low dose supplement of lipidated curcumin in healthy middle aged people. Nutr J. 2012 Sep 26;11:79.
Frautschy, SA. Bioavailability, brain concentrations, activity and dose-response of Longvida® SLCP. 38th Annual Meeting of the Society of Neuroscience , Washington DC, November 15, 2008.
Frautschy, SA et al. Omega 3 DHA and a bioavailable curcumin formulation synergize for Alzheimer prevention. 39th Annual Meeting of the Society of Neuroscience , Chicago, IL October 2009.
Frautschy, SA et al. Efficacy of Longvida® in relation to systemic availability in the brain. 39th Annual Meeting of the Society of Neuroscience , Chicago, IL October 2009.
Gota et al. afety and pharmacokinetics of a solid lipid curcumin particle formulation in osteosarcoma patients and healthy volunteers. J Ag Food Chem 2010 58(4): 2095-2099.
Ray B, Lahiri DK. Neuroinflammation in Alzheimer’s disease: different molecular targets and potential therapeutic agents including curcumin. Curr Opin Pharmacol. 2009 Aug;9(4):434-44.
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Q: Is nanotechnology safe?
A: It really comes down to what substance is being discussed. If it’s a natural substance, a food or spice for example, breaking down the particles just makes it easier for the body to digest and absorb, and doesn’t cause a problem. However if it’s a potentially dangerous substance, then applying nanotechnology is only going to make it more dangerous, for exactly the same reason – the body absorbs it more readily.
The idea of nanotechnology has actually been used for centuries in human nutrition and isn’t that new or novel. All nanotechnology really is, is breaking down a substance into very small particles (flour and icing sugar are two examples). In India, when turmeric is used in a curry, it is often broken down into a very fine powder, and then emulsified and heated in oil to release its full absorption potential. Scientists suspect this is why Indian people benefit from the health-promoting effects of the curcumin, which usually isn’t well absorbed by the body. The technologies applied to our Optimized Curcumin mimic this effect – first it is broken down into a fine (nano-sized) powder, and then the beadlets of curcumin are coated with a lipid matrix. Both of these aspects are equally important for absorption purposes, and this is similar to how Indian people have been consuming curcumin for centuries.
Q: Why does AOR still offer Curcumin-95 if Longvida® curcumin is better?
A: There will always be consumers who abide by holistic philosophy and prefer pure, natural extracts that have not been modified or altered by modern technologies.
Investigation of the effects of solid lipid curcumin on cognition and mood in a healthy older population.
J Psychopharmacol. 2014 Oct 2.
Cox KH, Pipingas A, Scholey AB.
Curcumin possesses many properties which may prevent or ameliorate pathological processes underlying age-related cognitive decline, dementia or mood disorders. These benefits in preclinical studies have not been established in humans. This randomized, double-blind, placebo-controlled trial examined the acute (1 and 3 h after a single dose), chronic (4 weeks) and acute-on-chronic (1 and 3 h after single dose following chronic treatment) effects of solid lipid curcumin formulation (400 mg as Longvida®) on cognitive function, mood and blood biomarkers in 60 healthy adults aged 60-85. One hour after administration curcumin significantly improved performance on sustained attention and working memory tasks, compared with placebo. Working memory and mood (general fatigue and change in state calmness, contentedness and fatigue induced by psychological stress) were significantly better following chronic treatment. A significant acute-on-chronic treatment effect on alertness and contentedness was also observed. Curcumin was associated with significantly reduced total and LDL cholesterol and had no effect on hematological safety measures. To our knowledge this is the first study to examine the effects of curcumin on cognition and mood in a healthy older population or to examine any acute behavioral effects in humans. Results highlight the need for further investigation of the potential psychological and cognitive benefits of curcumin in an older population.
Diverse effects of a low dose supplement of lipidated curcumin in healthy middle aged people.
Nutr J. 2012 Sep 26;11:79.
Disilvestro RA, Joseph E, Zhao S, Bomser J.
BACKGROUND: Curcumin extracts of turmeric are proposed to produce health benefits. To date, human intervention studies have focused mainly on people with existing health problems given high doses of poorly absorbed curcumin. The purpose of the current study was to check whether in healthy people, a low dose of a lipidated curcumin extract could alter wellness-related measures.
METHODS: The present study was conducted in healthy middle aged people (40-60 years old) with a low dose of curcumin (80 mg/day) in a lipidated form expected to have good absorption. Subjects were given either curcumin (N = 19) or placebo (N = 19) for 4 wk. Blood and saliva samples were taken before and after the 4 weeks and analyzed for a variety of blood and saliva measures relevant to health promotion.
RESULTS: Curcumin, but not placebo, produced the following statistically significant changes: lowering of plasma triglyceride values, lowering of salivary amylase levels, raising of salivary radical scavenging capacities, raising of plasma catalase activities, lowering of plasma beta amyloid protein concentrations, lowering of plasma sICAM readings, increased plasma myeloperoxidase without increased c-reactive protein levels, increased plasma nitric oxide, and decreased plasma alanine amino transferase activities.
CONCLUSION: Collectively, these results demonstrate that a low dose of a curcumin-lipid preparation can produce a variety of potentially health promoting effects in healthy middle aged people.
Safety and Pharmacokinetics of a Solid Lipid Curcumin Particle Formulation in Osteosarcoma Patients and Healthy Volunteers.
J Agric Food Chem. 2010; 58(4): 2095-2099.
Gota VS et al.
Curcumin is the lipid-soluble antioxidant compound obtained from the rhizome of Curcuma longa Linn, also known as turmeric. Curcumin targets multiple chemotherapeutic and inflammatory pathways and has demonstrated safety and tolerability in humans, supporting its potential as a therapeutic agent; however, the clinical literature lacks conclusive evidence supporting its use as a therapeutic agent due to its low bioavailability in humans. The purpose of this study was to quantify plasma levels of free curcumin after dosing of a solid lipid curcumin particle (SLCP) formulation versus unformulated curcumin in healthy volunteers and to determine its tolerability and dose−plasma concentration relationship in late-stage osteosarcoma patients. Doses of 2, 3, and 4 g of SLCP were evaluated in 11 patients with osteosarcoma. Plasma curcumin levels were measured using a validated high-performance liquid chromatography method. The limit of detection of the assay was 1 ng/mL of curcumin. In healthy subjects, the mean peak concentration of curcumin achieved from dosing 650 mg of SLCP was 22.43 ng/mL, whereas plasma curcumin from dosing an equal quantity of unformulated 95% curcuminoids extract was not detected. In both healthy individuals and osteosarcoma patients, high interindividual variability in pharmacokinetics and nonlinear dose dependency was observed, suggesting potentially complex absorption kinetics. Overall, good tolerability was noted in both healthy and osteosarcoma groups.