DISCUSSION: Curcuma longa is traditionally used in Herbal medicine as an anti-inflammatory to help relieve joint pain and provides antioxidants for the maintenance of good health.
|NPN (what's this?)||Product Code||Size||Per Capsule||Vegetarian|
|80034700||AOR04247||60 Vegi-Caps||133.3 mg||Vegetarian|
|Serving Size: 1 Capsule|
|Longvida® Optimized Curcumin* (from Curcuma longa root 25-30:1)||133.3 mg|
|Non-medicinal ingredients: ascorbyl palmitate, microcrystalline cellulose, soy lecithin, stearic acid, maltodextrin, silicon dioxide. Capsule: hypromellose. *LONGVIDA® is a registered trademark of Verdure Sciences Inc. International patent pending.|
AOR Guarantees: that no ingredients not listed on the label have been added to the product. Contains no wheat, gluten, nuts, peanuts, sesame seeds, sulphites, mustard, eggs, dairy, fish, shellfish or any animal byproduct.
Adult Dosage: Take 1 to 2 capsules daily, or as directed by a qualified health care practitioner.
Cautions: Consult a health care practitioner prior to use if you are taking antiplatelet medication or blood thinners, or if you have gallstones, a bile duct obstruction, stomach ulcers or excess stomach acid. Consult a health care practitioner if symptoms persist or worsen.
Pregnancy/Nursing: Consult a health care practitioner prior to use
100% pure curcumin from Longvida® Optimized Curcumin
The information and product descriptions appearing on this website are for information purposes only, and are not intended to provide or replace medical advice to individuals from a qualified health care professional. Consult with your physician if you have any health concerns, and before initiating any new diet, exercise, supplement, or other lifestyle changes.
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Do Not Confuse Turmeric Root with Curcumin!
Curcumin is a powerful anti-inflammatory derived from turmeric root. Turmeric root supplements absolutely do not offer the same benefits as those containing isolated curcumin. Curcumin is the most potent component of the turmeric root. Unfortunately, turmeric root contains less than 2% of curcumin making it ineffective for any health benefits. In addition, over 95% of all clinical studies have been conducted using isolated curcumin and NOT with the turmeric root. Even 750 mg of a 10:1 ratio extract of turmeric will deliver no more than 150 mg of the active curcumin. But given the poor bioavailability (the amount of the active compound that reaches the target site or site of action) of this compound, the amount you actually get is likely far less than that. Clinical studies suggest that the bioavailability is less than 5%, making even standard 95% curcumin formulations fairly ineffective. As for a significantly weakened turmeric root formula? That becomes essentially useless!
Longvida®, a highly bioavailable form of curcumin, is the result of testing over two hundred formulations and has taken more than ten years to develop. In a human bioavailability study involving patients, Longvida® curcumin was shown to be far more bioavailable than regular curcumin. This formulation was developed and patented by UCLA Medical School and is licensed exclusively to AOR.
Gota and colleagues did a safety and bioavailability study on healthy volunteers versus patients. Subjects were given doses between 400 and 1,200 mg of curcumin in solid lipid particle form (equivalent to 3 to 9 capsules of Curcumin Active). All doses showed significant absorption into the bloodstream over 8 hours with no adverse events.
Longvida® Curcumin in Humans
A human trial on curcumin showed statistically significant effects on clinical endpoints in a healthy population. The fact that such a low dose (80 mg) was needed to achieve effects in only 30 days is an interesting and unique finding as well, and adds to the substantial amount of pharmacokinetic and pharmacodynamic data compiled on Longvida®. The results of the study suggest that curcumin can produce beneficial effects in people who are without immediate disease states. The study was conducted on 38 healthy middle aged people between the age of 40 and 60 who were either given a dose of 80 mg/day of Longvida® curcumin extract for four weeks or were a part of the 19 person placebo group. The study is particularly interesting because the relatively small dose of curcumin, from Longvida® which was used, exerted a variety of health promoting effects leading researchers to presume that a significant amount of the curcumin was absorbed, although not tested directly.
Blood sample readings collected from test subjects to assess nitric oxide and sICAM molecules were notably affected by the curcumin. Interestingly, other markers of inflammation and free radicals/toxic species that cause inflammation and damage to cells were also significantly lowered. Both direct and indirect antioxidant actions of curcumin were evident in the subjects; these findings are consistent with in vitro and animal studies used to measure increases in curcumin induced antioxidant enzyme activity.
Numerous supplements on the market contain the curcumin extract of turmeric. However, many of these are poorly absorbed and offer little value in terms of therapeutic benefit due to their poor bioavailability.
New Technology – Better Products!
Over the last ten years a great deal of research has been done to develop formulations that improve the bioavailability of curcumin. The goal has been to deliver more of the active molecules to the body in a much lower daily dose; as few as one to three capsules per day. There have been a number of technologies developed, but the one that has provided the most compelling evidence is the Longvida® patented technology. It is so effective that other formulas won’t even compare themselves to Longvida® curcumin.
Longvida® curcumin was introduced to Canada exclusively by AOR in 2011. Curcumin Active is clinically proven to deliver several health benefits as a result of its high bioavailability and has the following advantages:
Curcumin Active TM consists of solid lipid particles (SLP) which are tiny particles that have a protected layer that provides a phenomenal increase in stability, potency and effectiveness. Unlike regular curcumin that is easily broken down by stomach acids, Curcumin Fast Relief particles are resistant to acid breakdown. Even more important is the fact that these tiny particles are absorbed very rapidly. This means that they deliver all of the health benefits of curcumin, including pain relief, reduced inflammation, antioxidant properties and other effects much faster than any other curcumin product.
Try Curcumin Active TM today and start feeling the benefits of a real high-potency, high-bioavailability curcumin supplement.
Begum et al. Curcumin Structure-Function, Bioavailability, and Efficacy in Models of Neuroinflammation and Alzheimer’s Disease. J Pharmacol Exp Ther. 2008 Jul;326(1):196-208.
Dadhaniya P, Patel C, Muchhara J, Bhadja N, Mathuria N, Vachhani K, Soni MG. Chronic safety of Longvida. Food Chem Toxicol. 2011 May 6.
Disilvestro RA, Joseph E, Zhao S, Bomser J. Diverse effects of a low dose supplement of lipidated curcumin in healthy middle aged people. Nutr J. 2012 Sep 26;11:79.
Frautschy, SA. Bioavailability, brain concentrations, activity and dose-response of Longvida® SLCP. 38th Annual Meeting of the Society of Neuroscience , Washington DC, November 15, 2008.
Frautschy, SA et al. Omega 3 DHA and a bioavailable curcumin formulation synergize for Alzheimer prevention. 39th Annual Meeting of the Society of Neuroscience , Chicago, IL October 2009.
Frautschy, SA et al. Efficacy of Longvida® in relation to systemic availability in the brain. 39th Annual Meeting of the Society of Neuroscience , Chicago, IL October 2009.
Gota et al. afety and pharmacokinetics of a solid lipid curcumin particle formulation in osteosarcoma patients and healthy volunteers. J Ag Food Chem 2010 58(4): 2095-2099.
Ray B, Lahiri DK. Neuroinflammation in Alzheimer’s disease: different molecular targets and potential therapeutic agents including curcumin. Curr Opin Pharmacol. 2009 Aug;9(4):434-44.
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Q: Why does AOR still offer Curcumin-95 if Longvida® curcumin is better?
A: There will always be consumers who abide by holistic philosophy and prefer pure, natural extracts that have not been modified or altered by modern technologies.
Diverse effects of a low dose supplement of lipidated curcumin in healthy middle aged people.
Nutr J. 2012 Sep 26;11:79.
Disilvestro RA, Joseph E, Zhao S, Bomser J.
BACKGROUND: Curcumin extracts of turmeric are proposed to produce health benefits. To date, human intervention studies have focused mainly on people with existing health problems given high doses of poorly absorbed curcumin. The purpose of the current study was to check whether in healthy people, a low dose of a lipidated curcumin extract could alter wellness-related measures.
METHODS: The present study was conducted in healthy middle aged people (40-60 years old) with a low dose of curcumin (80 mg/day) in a lipidated form expected to have good absorption. Subjects were given either curcumin (N = 19) or placebo (N = 19) for 4 wk. Blood and saliva samples were taken before and after the 4 weeks and analyzed for a variety of blood and saliva measures relevant to health promotion.
RESULTS: Curcumin, but not placebo, produced the following statistically significant changes: lowering of plasma triglyceride values, lowering of salivary amylase levels, raising of salivary radical scavenging capacities, raising of plasma catalase activities, lowering of plasma beta amyloid protein concentrations, lowering of plasma sICAM readings, increased plasma myeloperoxidase without increased c-reactive protein levels, increased plasma nitric oxide, and decreased plasma alanine amino transferase activities.
CONCLUSION: Collectively, these results demonstrate that a low dose of a curcumin-lipid preparation can produce a variety of potentially health promoting effects in healthy middle aged people.
Safety and Pharmacokinetics of a Solid Lipid Curcumin Particle Formulation in Osteosarcoma Patients and Healthy Volunteers.
J Agric Food Chem. 2010; 58(4): 2095-2099.
Gota VS et al.
Curcumin is the lipid-soluble antioxidant compound obtained from the rhizome of Curcuma longa Linn, also known as turmeric. Curcumin targets multiple chemotherapeutic and inflammatory pathways and has demonstrated safety and tolerability in humans, supporting its potential as a therapeutic agent; however, the clinical literature lacks conclusive evidence supporting its use as a therapeutic agent due to its low bioavailability in humans. The purpose of this study was to quantify plasma levels of free curcumin after dosing of a solid lipid curcumin particle (SLCP) formulation versus unformulated curcumin in healthy volunteers and to determine its tolerability and dose−plasma concentration relationship in late-stage osteosarcoma patients. Doses of 2, 3, and 4 g of SLCP were evaluated in 11 patients with osteosarcoma. Plasma curcumin levels were measured using a validated high-performance liquid chromatography method. The limit of detection of the assay was 1 ng/mL of curcumin. In healthy subjects, the mean peak concentration of curcumin achieved from dosing 650 mg of SLCP was 22.43 ng/mL, whereas plasma curcumin from dosing an equal quantity of unformulated 95% curcuminoids extract was not detected. In both healthy individuals and osteosarcoma patients, high interindividual variability in pharmacokinetics and nonlinear dose dependency was observed, suggesting potentially complex absorption kinetics. Overall, good tolerability was noted in both healthy and osteosarcoma groups.