DISCUSSION: Lysine, Vitamin C and Hyaluronic Acid contains ingredients that help in the development and maintenance of bones and cartilage, as well as aid in collagen and connective tissue formation.
|NPN (what's this?)||Product Code||Size||Per Capsule||Vegetarian|
|80028874||AOR04273||60 Vegi-Caps||224 mg||Vegetarian|
|Serving Size: 1 Capsule||Amount Per Serving|
|Hyaluronic Acid||98.5 mg|
|Vitamin C||50 mg|
|Non-medicinal ingredients: microcrystalline cellulose, silicon dioxide. Capsule: hypromellose.|
AOR Guarantees: that no ingredients not listed on the label have been added to the product. Contains no wheat, gluten, corn, nuts, peanuts, sesame seeds, sulphites, mustard, dairy, soy, eggs, fish, shellfish, or any animal byproduct.
Adult Dosage: Take 1 capsule twice per day as directed by a qualified health care practitioner.
Cautions: Consult a health care practitioner prior to use if you are following a low protein diet or for use beyond 3 months.
Pregnancy/Nursing: Consult a health care practitioner prior to use
Hyaluronic acid and Lysine - biofermentation Vitamin C - pharmaceutical synthesis
The information and product descriptions appearing on this website are for information purposes only, and are not intended to provide or replace medical advice to individuals from a qualified health care professional. Consult with your physician if you have any health concerns, and before initiating any new diet, exercise, supplement, or other lifestyle changes.
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What is Hyaluronic Acid?
Hyaluronic acid is a protective substance found in the synovial fluid and connective tissue of movable joints. Hyaluronic acid is a naturally occurring substance that is essential for joint mobility. The synovial fluid is a thick fluid surrounding the joints that acts as a lubricant and shock absorber. It forms a thin layer at the surface of cartilage, reducing friction, facilitating movement and providing nourishment. As a key component of the synovial fluid, hyaluronic acid forms a thick gel that lubricates and protects joints. Hyaluronic acid is found throughout the body but high concentrations are found in the skin and joints.
Hyaluronic Acid for Joint Protection
Normal synovial fluid contains 3-4 mg/ml of hyaluronic acid. Hyaluronic acid helps protect joints by augmenting the viscosity of the synovial fluid, by increasing the elasticity of the cartilage found in joints and because of its anti-inflammatory effect. Recent studies have shown that serum hyaluronic acid levels are a useful marker for the activity and severity of rheumatoid disease. Supplementation with hyaluronic acid reduces pain and improves function in patients with osteoarthritis of the knee. These effects are thought to be attributable to the return of a more normal synovial fluid, improved viscoelasticity, improved cartilage biosynthesis, anti-inflammatory and analgesic effects. Hyaluronic acid also promotes wound healing; it is thought that its cementing ability allows room for white blood cells, which increases the speed of recovery.
Protection and Healing from Vitamin C and Lysine
Many people know that vitamin C is an important nutrient and antioxidant, but it is less well known that this versatile nutrient also plays an essential role in healthy joint function and repair. In the body, vitamin C and the amino acid lysine are required for the production of collagen. Collagen is a type of connective tissue that is found throughout the body, and which is an essential component of various body tissues including cartilage, ligaments, bones, teeth and skin. As our joints undergo everyday wear and tear, the body produces new collagen, which is used to maintain and repair the cartilage and other connective tissues of the joints. Supplemental vitamin C and lysine have been shown to enhance collagen production in the body, providing additional support for the repair and maintenance of healthy joints.
Hylauronic Acid’s anti-inflammatory activity
Hyaluronic acid has been shown to exert anti-inflammatory activity through its effect on nitric oxide, a molecule that is pivotal in synovial inflammation, cartilage and meniscus degeneration. Serum hyaluronic acid levels were shown to be a useful marker for the activity and severity of disease activity in rheumatoid arthritis patients.
Studies prove that hyaluronic acid increases cartilage production in the joint
Studies show that the hyaluronic acid content in osteoarthritic cartilage is much lower than normal and that hyaluronic acid supplementation lessens pain and improves function in patients with osteoarthritis of the knee. In vitro studies have clearly demonstrated that the presence of hyaluronic acid has a stimulatory effect on chondrocyte metabolism. In other words, hyaluronic acid increases the activity of the cells responsible for cartilage production and maintenance.
Hyaluronic acid reduces pain levels in osteoarthritis patients
In a study involving sixty-two patients with symptoms of bilateral medial tibiofemoral knee osteoarthritis knee pain (both knees), treatment was administered to them with a single hyaluronic acid injection (66 mg) into each knee. The second group was treated with a hyaluronic acid injection (49.5 mg) plus diclofenac sodium (5 mg) into both knees and the third group was treated with a hyaluronic acid injection (49.5 mg) plus sodium clodronate (5 mg) in both knees. Blood tests were administered to all patients in order to measure erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) immediately before and at 6-month follow-up.
The results indicated that hyaluronic acid on its own and combined with sodium clodronate or diclofenac sodium allowed for a significant improvement in the three and six month follow up pain scores. At 6-month follow-up, hyaluronic acid therapy plus sodium clodronate was of more benefit in terms of improving the pain scores. A large improvement in CRP and ESR was noted at the 6-month follow-up in each group receiving treatment. No notable difference was found when the percentage change from baseline related to these parameters was compared between the groups. There were no dropouts in any of the groups. There were no serious adverse resulting effects.
Additional research is needed in order to determine the results of therapies using hyaluronic acid alone or in combination with diclofenac sodium or sodium clodronate in patients affected with knee osteoarthritis.
Osteoarthritis, rhematoid arthritis and just aging in general are associated with cartilage degeneration in the joints. Hyaluronic acid is a very popular supplement that hopes to replenish hyaluronic acid levels in synovial fluid, the fluid that surrounds joints like the knee. Hyaluronic acid nourishes and repairs cartilage, and those who suffer from joint degeneration often turn to this supplement in an attempt to avoid conventional drugs or knee replacement surgery.
Most original studies administered hyaluronic acid by injection directly into the joint rather than orally. The effectiveness of oral hyaluronic acid is therefore still being debated.
Hyaluronic acid was originally sourced from chicken combs, but vegetarian sources are now being demanded.
AOR’s Lysine, Vitamin C and Hyaluronic Acid contains a unique and highly effective combination of natural ingredients to support and protect joint function. The product contains a superior, high-potency vegetarian source of hyaluronic acid that has a lower molecular weight. This lower molecular weight means that the molecules are smaller, which allows the product to be more easily absorbed by the body. Vitamin C and Lysine provide additional support for enhanced collagen formation and healthy joint repair.
Akmal M, Singh A, Anand A, Kesani A, Aslam N, Goodship A, Bentley G. The effects of hyaluronic acid on articular chondrocytes. J Bone Joint Surg Br. 2005 Aug;87(8):1143-9.
Carrr A.C. and Frier B. Toward a new recommended dietary allowance for vitamin C based on antioxidant and health effects in humans. American Journal of Clinical Nutrition. 1999; 69(6): 1086-1107
Louthrenoo W, Kongtawelert P, Sivasomboon C, Sukitawut W. Correlation between serum hyaluronan and disease activity and severity in Thai patients with rheumatoid arthritis. J Med Assoc Thai. 2001 May;84(5):622-7.
Lu L, Leng Y, Cnen Y. An experiment study on wound healing with exogenous hyaluronic acid. Zhonghua Zheng Xing Wai Ke Za Zhi. 2000 Jan;16(1):30-3. Chinese.
Moskowitz RW. Hyaluronic acid supplementation. Curr Rheumatol Rep. 2000 Dec;2(6):466-71. Review.
Williams JM, Zhang J, Kang H, Ummadi V, Homandberg GA. The effects of hyaluronic acid on fibronectin fragment mediated cartilage chondrolysis in skeletally mature rabbits. Osteoarthritis Cartilage. 2003 Jan;11(1):44-9.
Q: If someone is bordering high blood pressure and is salt sensitive, should they refrain from taking hyaluronic acid?
A: Injected pharmaceutical versions of HA can cause high blood pressure as a side effect. These effects haven’t been noted in oral supplements, but it doesn’t mean they don’t exist in a small portion of the population. If this is a concern, consulting a doctor is always preferable.
Tolerability and short-term effectiveness of hylan G-F 20 in 4253 patients with osteoarthritis of the knee in clinical practice.
Curr Med Res Opin. 2005 Aug;21(8):1261-9.
Kemper F, Gebhardt U, Meng T, Murray C.
OBJECTIVE: To determine the tolerability and short-term effectiveness of hylan G-F 20 (Synvisc) in patients with symptomatic osteoarthritis (OA) of the knee in standard clinical practice.
RESEARCH DESIGN AND METHODS: Over 800 orthopedic surgeons in Germany recorded adverse events (AEs) for approximately five consecutive patients each following 3 weekly intra-articular hylan G-F 20 injections. Patients assessed their pain on a 4-point scale before and 3 weeks after the first injection. Potential risk factors for local AEs and possible predictors of short-term effectiveness of hylan G-F 20 were explored with logistic regression.
RESULTS: 4253 patients were treated with 12699 injections by 840 physicians at 720 sites. Local, treatment related AEs (n = 302) were reported in 180 patients (4.2% of patients; 2.4% of injections). The most frequently reported AEs were joint effusion (2.4% of patients), joint swelling (1.3%), arthralgia (1.2%), joint warmth (0.6%), and injection site erythema (0.3%). Most AEs were mild (21.4%) to moderate (40.3%) in nature. One patient experienced a serious AE of severe swelling and synovial fluid accumulation judged as possibly treatment related. Patients < 70 years old, patients with a longer time since diagnosis, and those previously treated with visco-supplementation were more likely to experience a local AE. Pain significantly (p < 0.0001) decreased 3 weeks after the first injection compared with before treatment. Potential predictors of hylan G-F 20 short-term effectiveness were being underweight, male gender, shorter time since diagnosis, and severe baseline pain.
CONCLUSIONS: In this population of 4253 patients treated with hylan G-F 20 for OA knee pain, the overall incidence of local, treatment-related AEs was low and consistent with those reported in the current US product labeling and previously published studies. Additionally, short-term effectiveness was confirmed.
The effects of hyaluronic acid on articular chondrocytes.
J Bone Joint Surg Br. 2005 Aug;87(8):1143-9.
Akmal M, Singh A, Anand A, Kesani A, Aslam N, Goodship A, Bentley G.
The purpose of this study was to examine the effects of hyaluronic acid supplementation on chondrocyte metabolism in vitro. The clinical benefits of intra-articular hyaluronic acid injections are thought to occur through improved joint lubrication. Recent findings have shown that exogenous hyaluronic acid is incorporated into articular cartilage where it may have a direct biological effect on chondrocytes through CD44 receptors.Bovine articular chondrocytes were isolated and seeded into alginate constructs. These were cultured in medium containing hyaluronic acid at varying concentrations. Samples were assayed for biochemical and histological changes.There was a dose-dependent response to the exposure of hyaluronic acid to bovine articular chondrocytes in vitro. Low concentrations of hyaluronic acid (0.1 mg/mL and 1 mg/mL) significantly increase DNA, sulphated glycosaminoglycan and hydroxyproline synthesis. Immunohistology confirmed the maintenance of cell phenotype with increased matrix deposition of chondroitin-6-sulphate and collagen type II. These findings confirm a stimulatory effect of hyaluronic acid on chondrocyte metabolism.