Lysine, Vitamin C and Hyaluronic Acid

Lysine, Vitamin C and Hyaluronic Acid
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Lysine, Vitamin C and Hyaluronic Acid

  • Reduces joint friction and osteoarthritic pain
  • Prevents inflammation
  • Supports cartilage and collagen synthesis
  • New hyaluronic acid source – no longer from wheat and corn, making the product gluten free!
Lysine, Vitamin C and Hyaluronic Acid, 1.0 out of 5 based on 2 ratings

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DISCUSSION: Lysine, Vitamin C and Hyaluronic Acid contains ingredients that help in the development and maintenance of bones and cartilage, as well as aid in collagen and connective tissue formation.

NPN (what's this?)Product CodeSizePer CapsuleVegetarian
80028874AOR0427360 Vegi-Caps224 mgVegetarian
Supplement Facts
Serving Size: 1 CapsuleAmount Per Serving
Hyaluronic Acid98.5 mg
Lysine75 mg
Vitamin C50 mg
Non-medicinal ingredients: microcrystalline cellulose, silicon dioxide. Capsule: hypromellose.

AOR Guarantees: that no ingredients not listed on the label have been added to the product. Contains no wheat, gluten, corn, nuts, peanuts, sesame seeds, sulphites, mustard, dairy, soy, eggs, fish, shellfish, or any animal byproduct.

Adult Dosage: Take 1 capsule twice per day as directed by a qualified health care practitioner.

Cautions: Consult a health care practitioner prior to use if you are following a low protein diet or for use beyond 3 months.

Pregnancy/Nursing: Consult a health care practitioner prior to use

Hyaluronic acid and Lysine - biofermentation
Vitamin C - pharmaceutical synthesis

Main Indications:

  • Joint health
  • Skin health

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The information and product descriptions appearing on this website are for information purposes only, and are not intended to provide or replace medical advice to individuals from a qualified health care professional. Consult with your physician if you have any health concerns, and before initiating any new diet, exercise, supplement, or other lifestyle changes.

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Background Information

What is Hyaluronic Acid?
Hyaluronic acid is a protective substance found in the synovial fluid and connective tissue of movable joints. Hyaluronic acid is a naturally occurring substance that is essential for joint mobility. The synovial fluid is a thick fluid surrounding the joints that acts as a lubricant and shock absorber. It forms a thin layer at the surface of cartilage, reducing friction, facilitating movement and providing nourishment. As a key component of the synovial fluid, hyaluronic acid forms a thick gel that lubricates and protects joints. Hyaluronic acid is found throughout the body but high concentrations are found in the skin and joints.

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Hylauronic Acid’s anti-inflammatory activity
Hyaluronic acid has been shown to exert anti-inflammatory activity through its effect on nitric oxide, a molecule that is pivotal in synovial inflammation, cartilage and meniscus degeneration. Serum hyaluronic acid levels were shown to be a useful marker for the activity and severity of disease activity in rheumatoid arthritis patients.

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Market Trends

Osteoarthritis, rhematoid arthritis and just aging in general are associated with cartilage degeneration in the joints. Hyaluronic acid is a very popular supplement that hopes to replenish hyaluronic acid levels in synovial fluid, the fluid that surrounds joints like the knee. Hyaluronic acid nourishes and repairs cartilage, and those who suffer from joint degeneration often turn to this supplement in an attempt to avoid conventional drugs or knee replacement surgery.

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AOR Advantage

AOR’s Lysine, Vitamin C and Hyaluronic Acid contains a unique and highly effective combination of natural ingredients to support and protect joint function. The product contains a superior, high-potency vegetarian source of hyaluronic acid that has a lower molecular weight. This lower molecular weight means that the molecules are smaller, which allows the product to be more easily absorbed by the body. Vitamin C and Lysine provide additional support for enhanced collagen formation and healthy joint repair.


Akmal M, Singh A, Anand A, Kesani A, Aslam N, Goodship A, Bentley G. The effects of hyaluronic acid on articular chondrocytes. J Bone Joint Surg Br. 2005 Aug;87(8):1143-9.

Carrr A.C. and Frier B. Toward a new recommended dietary allowance for vitamin C based on antioxidant and health effects in humans. American Journal of Clinical Nutrition. 1999; 69(6): 1086-1107

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Q: If someone is bordering high blood pressure and is salt sensitive, should they refrain from taking hyaluronic acid?

A: Injected pharmaceutical versions of HA can cause high blood pressure as a side effect. These effects haven’t been noted in oral supplements, but it doesn’t mean they don’t exist in a small portion of the population. If this is a concern, consulting a doctor is always preferable.


Tolerability and short-term effectiveness of hylan G-F 20 in 4253 patients with osteoarthritis of the knee in clinical practice.
Curr Med Res Opin. 2005 Aug;21(8):1261-9. 

Kemper F, Gebhardt U, Meng T, Murray C.

OBJECTIVE: To determine the tolerability and short-term effectiveness of hylan G-F 20 (Synvisc) in patients with symptomatic osteoarthritis (OA) of the knee in standard clinical practice.
RESEARCH DESIGN AND METHODS: Over 800 orthopedic surgeons in Germany recorded adverse events (AEs) for approximately five consecutive patients each following 3 weekly intra-articular hylan G-F 20 injections. Patients assessed their pain on a 4-point scale before and 3 weeks after the first injection. Potential risk factors for local AEs and possible predictors of short-term effectiveness of hylan G-F 20 were explored with logistic regression.
RESULTS: 4253 patients were treated with 12699 injections by 840 physicians at 720 sites. Local, treatment related AEs (n = 302) were reported in 180 patients (4.2% of patients; 2.4% of injections). The most frequently reported AEs were joint effusion (2.4% of patients), joint swelling (1.3%), arthralgia (1.2%), joint warmth (0.6%), and injection site erythema (0.3%). Most AEs were mild (21.4%) to moderate (40.3%) in nature. One patient experienced a serious AE of severe swelling and synovial fluid accumulation judged as possibly treatment related. Patients < 70 years old, patients with a longer time since diagnosis, and those previously treated with visco-supplementation were more likely to experience a local AE. Pain significantly (p < 0.0001) decreased 3 weeks after the first injection compared with before treatment. Potential predictors of hylan G-F 20 short-term effectiveness were being underweight, male gender, shorter time since diagnosis, and severe baseline pain.
CONCLUSIONS: In this population of 4253 patients treated with hylan G-F 20 for OA knee pain, the overall incidence of local, treatment-related AEs was low and consistent with those reported in the current US product labeling and previously published studies. Additionally, short-term effectiveness was confirmed.


The effects of hyaluronic acid on articular chondrocytes.
J Bone Joint Surg Br. 2005 Aug;87(8):1143-9.
Akmal M, Singh A, Anand A, Kesani A, Aslam N, Goodship A, Bentley G.

The purpose of this study was to examine the effects of hyaluronic acid supplementation on chondrocyte metabolism in vitro. The clinical benefits of intra-articular hyaluronic acid injections are thought to occur through improved joint lubrication. Recent findings have shown that exogenous hyaluronic acid is incorporated into articular cartilage where it may have a direct biological effect on chondrocytes through CD44 receptors.Bovine articular chondrocytes were isolated and seeded into alginate constructs. These were cultured in medium containing hyaluronic acid at varying concentrations. Samples were assayed for biochemical and histological changes.There was a dose-dependent response to the exposure of hyaluronic acid to bovine articular chondrocytes in vitro. Low concentrations of hyaluronic acid (0.1 mg/mL and 1 mg/mL) significantly increase DNA, sulphated glycosaminoglycan and hydroxyproline synthesis. Immunohistology confirmed the maintenance of cell phenotype with increased matrix deposition of chondroitin-6-sulphate and collagen type II. These findings confirm a stimulatory effect of hyaluronic acid on chondrocyte metabolism.