Zinc-Copper Balance

Zinc-Copper Balance

Zinc-Copper Balance

A Balanced Ratio of Two Key Minerals

  • Reduces the risk of excess zinc
  • Supports healthy skin, prostate and immunity
  • Clinically backed ratio

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DISCUSSION: Zinc and copper are essential minerals critical to the maintenance of good health and connective tissue formation. Zinc supplementation is known to cause copper deficiency. Zinc-Copper BalanceTM provides a balanced ratio of zinc to copper, each in various forms in order to ensure optimal absorption.

NPN (what's this?) Product Code Size Per Capsule Vegetarian
80012983 AOR04291 100 Vegi-Caps 17 mg Vegan
Supplement Facts
Serving Size: 1 Capsule Amount Per Serving
Zinc (Citrate, Succinate, Fumarate) 15 mg
Copper (Citrate, Malate) 2 mg
Non-medicinal ingredients: microcrystalline cellulose, sodium stearyl fumarate, silicon dioxide. Capsule: hypromellose.

AOR Guarantees: that no ingredients not listed on the label have been added to the product. Contains no wheat, gluten, corn, nuts, dairy, soy, eggs, fish, shellfish or any animal byproduct.

Adult Dosage: Take 1 capsule daily with food, or as directed by a qualified health professional. Take a few hours before or after taking other medications.

Cautions: None known

Pregnancy/Nursing: Safe

Mineral extracts

Main Indications:

  • Mineral deficiencies
  • Immune function
  • Antioxidant
  • Prostate health

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The information and product descriptions appearing on this website are for information purposes only, and are not intended to provide or replace medical advice to individuals from a qualified health care professional. Consult with your physician if you have any health concerns, and before initiating any new diet, exercise, supplement, or other lifestyle changes.

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Background Information

Important Trace Minerals
Zinc and copper are essential minerals critical to health and commonly deficient in Western diets. An ongoing study tracking the nutritional intake of Americans found that 75% of older American adults were found failing to reach the RDA for zinc, and none of them achieved even the minimum recommended intake for copper. Yet while the importance of zinc is widely recognized, copper’s crucial role in our health has often been discounted. An overemphasis on zinc has resulted in widespread, unbalanced zinc supplementation. And that has serious implications for your long-term health.

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Ten to One
Both animal and human evidence suggests that, for optimal utilization of both minerals, the balance between zinc and copper should be about ten-to-one. This isn’t just a theoretical concern.

The Negative Effects of 23.5:1
In a series of human studies, putting volunteers on a diet and supplement regimen in which the ratio between zinc and copper was 23.5-to-one (and sometimes lower) – common zinc-to-copper ratios found in many multivitamins on health food store shelves – resulted in wide-ranging metabolic disturbances, including reduced levels of the copper-based antioxidants enzymes cytosolic superoxide dismutase and ceruloplasmin, increased total and LDL (“bad”) cholesterol, anemia, reductions in the body’s levels of enkephalins (natural pain-killing molecules), and cardiac dysfunction.

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Market Trends

While the importance of zinc is widely recognized especially for the immune system, copper’s crucial role in our health has often been discounted. An overemphasis on the importance of zinc and the disproven myth that copper is a dangerous free-radical have resulted in widespread, unbalanced zinc and copper supplementation. It’s common for supplements include too much zinc, and little or no copper, with the result that many – perhaps most – zinc supplements and multivitamin multivitamin and multimineral formulas contain potentially harmful zinc imbalances. If you are supplementing with zinc, be sure to get adequate copper as well.

AOR Advantage

AOR’s Zinc-Copper BalanceTM is formulated to provide the scientifically sound ratio of these essential minerals. This provides the health benefits of both nutrients while avoiding the pitfalls of unbalanced supplementation.


Allen GD, Klevay LM. Copper: an antioxidant nutrient for cardiovascular health. Curr Opin Lipidol. 1994 Feb; 5(1): 22-8.

Klevay LM. Lack of a recommended dietary allowance for copper may be hazardous to your health. J Am Coll Nutr. 1998 Aug; 17(4): 322-6.

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Is there a potential therapeutic value of copper and zinc for osteoporosis?
Proc Nutr Soc. 2002 May; 61(2): 181-5.
Lowe NM, Lowe NM, Fraser WD, Jackson MJ.

Osteoporosis is almost universal in very old age, and is a major cause of morbidity and mortality in the elderly of both sexes. Bone is lost at a rate of 0.2-0.5 %/year in both men and women after the age of 40-45 years. The causes of age-related changes in bone mass are multifactorial and include genetic predisposition, nutritional factors, endocrine changes, habitual exercise levels and body weight. Bone loss is accelerated to 2-5 % year immediately before and for up to 10 years post-menopause (Heaney, 1986). In women hormone-replacement therapy is effective in reducing the rate of bone loss caused by this peri-menopausal decrease in hormone levels (Smith & Studd, 1993); however, in men and older women (>10 years post-menopause) nutrition plays a key role in the rate of bone loss. One factor contributing to bone loss in the elderly may be a subclinical Zn and/or Cu deficiency, due to a reduced dietary intake of micronutrients and reduced absorption (Thomson & Keelan, 1986). Zn and Cu are essential cofactors for enzymes involved in the synthesis of various bone matrix constituents. Paradoxically, Ca supplementation may accentuate the problem of reduced Zn and Cu levels by impairing the absorption of simultaneously-ingested Zn and the retention of Cu (Snedeker et al. 1982; Grekas et al. 1988). The present paper will review the current literature on the potential benefits of Cu and Zn supplementation in reducing bone loss, and present new information on the effect of Ca supplementation on Zn and Cu status in post-menopausal women with osteoporosis.


Lack of a recommended dietary allowance for copper may be hazardous to your health.
J Am Coll Nutr. 1998 Aug; 17(4): 322-6.
Klevay LM.

The 10th edition of Recommended Dietary Allowances (RDA) did not include an RDA for copper; rather a safe and adequate daily intake was suggested. Criteria, history and uses of RDAs were summarized along with data on dietary intakes, balance and depletion experiments, low (fats and oils, skim milk and yogurt) and high (legumes, mushrooms, nuts and seeds) copper foods and hazards of zinc supplements. Bone disease and cardiovascular disease from diets-low in copper have been studied in animals for decades. Men and women fed diets close to 1 mg of copper per day, amounts quite frequent in the US, responded similarly to deficient animals with reversible, potentially harmful changes in blood pressure control, cholesterol and glucose metabolism, and electrocardiograms. Women supplemented with trace elements including copper experienced beneficial effects on bone density. These data exceed similar data on magnesium, selenium and zinc and are sufficient for establishing an RDA. Association between osteoporosis and low copper status deserves further inquiry. Augmenting low copper diets with high copper foods may be beneficial. Committees that establish RDAs should return to the traditions of the first nine editions and make recommendations that promote health and nutritional welfare, meet functional needs, prevent disease and promote public welfare.


Requirements and toxicity of essential trace elements, illustrated by zinc and copper.
Am J Clin Nutr. 1995 Mar; 61(3 Suppl): 621S-624S.
Sandstead HH.

Early signs of toxicity of essential trace elements are important. Some trace elements are available over-the-counter (OTC) and/or are present at industrial waste sites. Physicochemically similar trace elements compete for ligands, impairing functions, which is exemplified by the zinc-copper antagonism described long ago by Van Campen, Hill and Matrone, and Klevay. Intestinal absorption of copper is inhibited by zinc. Thus risk of copper deficiency is increased when the molar ratio of zinc to copper (Zn:Cu) is high. As shown by experiments, copper deficiency can occur in humans. Manifestations include decreased erythrocyte copper-zinc superoxide dismutase, increased low-density-lipoprotein cholesterol, decreased high-density-lipoprotein cholesterol, decreased glucose clearance, decreased methionine and leucine enkephalins, and abnormal cardiac function. Calculation of a preliminary reference dose for OTC zinc that assumed high bioavailability and uncertain copper intakes established 9 mg as a safe amount for 60-kg adults.


Copper: an antioxidant nutrient for cardiovascular health.
Current Opinion in Lipidology. 1994 Feb; 5(1): 22-8.
Allen GD, Klevay LM.

Dietary copper often is low in the Western diet; low intakes may affect all stages of atherosclerosis adversely. Impaired oxidative defense in copper deficiency contributes to hypercholesterolemia and impaired prostaglandin metabolism. Free copper ion does not exist in vivo; some in-vitro experiments are conducted with millions-fold excesses.