DISCUSSION: Thyro Support™ contains iodine to help in the function of the thyroid gland as well as other minerals and natural ingredients for the maintenance of good health.
|NPN (what's this?)||Product Code||Size||Per Capsule||Vegetarian|
|80024543||AOR04236||90 Vegi-Caps||518 mg||Vegetarian|
|Serving Size: 3 Capsules|
|Iodine (Potassium Iodide)||500 mcg|
|Coleus forskohlii extract (10% forskolin)||250 mg|
|Bacopa monnieri extract (50% bacosides A & B)||300 mg|
|Copper (malate)||500 mcg|
|Zinc (citrate, fumarate)||5 mg|
|Selenium (Selenomethionine)||55 mcg|
|Non-medicinal ingredients: dicalcium phosphate, maltodextrin. Capsule: hypromellose.|
AOR Guarantees: that no ingredients not listed on the label have been added to the product. Contains no wheat, gluten, peanuts, sesame seeds, sulphites, mustard, soy, dairy, eggs, shellfish or any animal byproduct.
Adult Dosage: Take 1 capsule three times a day with food or as directed by a qualified health care practitioner. Take a few hours before or after taking other medications. For use beyond 4 weeks, consult a health care practitioner
Cautions: May cause gastrointestinal disturbances such as epigastric burning sensation and nausea. Discontinue use if rash develops. Consult a health care practitioner prior to use if you are following a low protein diet.
Pregnancy/Nursing: Do not use
Bacopa & Coleus - Natural botanical extracts;
Minerals - Pharmaceutical synthesis;
L-Tyrosine - Biofermentation;
The information and product descriptions appearing on this website are for information purposes only, and are not intended to provide or replace medical advice to individuals from a qualified health care professional. Consult with your physician if you have any health concerns, and before initiating any new diet, exercise, supplement, or other lifestyle changes.
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The Importance of Hormones
The biochemical actions of hormones accurately reflect the word’s original translation from the Greek orµn, which literally means ‘to set in motion’. Far more than merely chemical messengers, hormones are generated by the glands to be the initiating forces that stimulate a cascade of biological activity resonating throughout the entire body. Of these, none are more critical than the hormones produced by the thyroid glands.
Thyroid hormones are universally important, playing central roles in the healthy function of the human cardiovascular, nervous, muscular and skeletal systems, and their effects extend to the health of bowels and even skin, nails and hair. The thyroid gland is the primary regulator of the body’s metabolic rate. Hypothyroidism is a medical condition defined by the insufficient production of thyroid by the thyroid gland. However, in recent decades a less severe – but more widespread – version of the condition known as subclinical hypothyroidism has been identified.
Subclinical hypothyroidism, although not officially recognized by conventional medicine, affects up to 15% of the elderly and can lead to fatigue, weight gain, cardiovascular disturbances, oversensitivity to cold, dry skin, brittle nails, constipation and overall weakness and depression. For these reasons, measures taken to ensure the optimum vitality of one’s thyroid production can be invaluable, and such measures (which would augment a balanced diet) can be achieved most efficiently through proper supplementation.
The Basics: Tyrosine & Iodine
Essential nutrients for thyroid supplementation would include the basic thyroid necessities of tyrosine and iodine. The former is an amino acid that is an essential precursor for triiodothyronine (or T3, the most powerful thyroid hormone, affecting almost every bodily process, including body temperature, heart rate, and metabolic growth) as well as thyroxine (or T4, which plays a ‘supporting’ role to T3). T3 is four to ten times more biologically active than T4. The gland secretes mostly T4 but most of this T4 is converted to T3 in the periphery and around 80% of the circulating T3 is derived from T4. T4 is converted to T3 through the removal of one iodine molecule in the liver, spleen or the kidneys. Only the unbound thyroid hormones can access target cell receptors, and less than 1% of circulating T3 and 0.1% of T4 is unbound. Iodine, on the other hand, is an essential mineral that actually forms part of the atomic composition of both T3 and T4. One-quarter of the body’s entire iodine supply is found in the thyroid gland.
Several other ingredients have proven to be of benefit to the proper functioning of the thyroid such as Coleus forskohlii, Bacopa monnieri, zinc, copper, and selenium.
The Ayurvedic herb Coleus forskohlii is especially useful in cases of hypothyroidism because it increases thyroid hormone production and release.
Bacopa monnieri is a plant extract of the water hyssop, a plant valued in India for its neuroprotective activity and its ability to enhance cognitive function. It may enhance the concentration of T4.
The Ayurvedic herb Coleus forskohlii, and its active constituent Forskolin, has demonstrated its ability to raise the production and release of thyroid hormones in animal and in-vitro studies. Several benefits that have been noted from taking forskolin. One particular study examined the effect of forskolin on male body composition, testosterone, metabolic rate, and blood pressure in overweight and obese men. Forskolin was able to produce favorable changes in the body composition of those taking it over a twelve week period at a dosage of 250 mg’s of extract taken twice per day. It was able to lower fat mass and increase lean body mass as compared to the placebo group. It also caused an increase in free testosterone levels.
Studies have revealed that Coleus forskohlii stimulates adenylate cyclase, which in turn produces cyclic adenosine mono phosphate (cAMP), an important regulator of cellular function, energy expediture and a hormonal response modifier. Studies have shown that cells from hypothyroid rats produce less cAMP. cAMP is an important redox agent with attributes similar to ATP, CoQ10 and NADH whi are important for energy production.
Studies in male mice showed that Bacopa possesses powerful thyroid stimulating effects, increasing T4 concentration by 41% after supplementation for 15 days.
Numerous studies have made it clear that normal thyroid status is dependent on the presence of many trace elements for both the synthesis and metabolism of thyroid hormones. Iodine is most important as a component of the hormones, thyroxine and 3,3′,5-tri-iodothyronine (T3) and iodine deficiency may affect approximately one billion people throughout the world.
Selenium is essential for normal thyroid hormone metabolism being involved with selenium-containing iodothyronine de-iodinases that control the synthesis and degradation of the biologically active thyroid hormone, T3.
Other important thyroid nutrients and enzymes
The roles of iron, zinc and copper in the thyroid are less well defined but sub- or supraoptimal dietary intakes of all these elements can adversely affect thyroid hormone metabolism. Additionally, selenoperoxidases and thioredoxin reductase protect the thyroid gland from peroxides produced during the synthesis of hormones.
Thyroid drugs such as Synthroid are commonly taken by people who have hypothyroidism. What many people are unaware of is that adrenal gland function (stress hormones) are closely tied in with the function of the thyroid gland and thyroid hormones. When supporting the thyroid, it is often necessary to also support the adrenals.
Long before Coleus forskohlii was made popular for weight loss, AOR’s Thyro Support provided this coveted herb to support thyroid function. Thyro Support contains all of the necessary nutrients for optimal thyroid function along with ayurvedic herbs to enhance its activity. For additional effectiveness, Thyro Support can be combined with Opti-Guggul II and/or Ortho•Adapt.
Ammon, H.P., and Muller, A.B., “Forskolin: From an Ayurvedic Remedy to a Modern Agent,” Planta Med Dec.6 (1985) : 473-7.
Arthur JR, Beckett GJ. Thyroid function. Br Med Bull. 1999;55(3):658-68.
Chanoine JP. Selenium and thyroid function in infants, children and adolescents. Biofactors. 2003;19(3-4):137-43. Review.
Ealey PA, Kohn LD, Marshall NJ, Ekins RP. Forskolin stimulation of naphthylamidase in guinea pig thyroid sections detected with a cytochemical bioassay. Acta Endocrinol (Copenh). 1985 Mar;108(3):367-71.
Godard MP, Johnson BA, Richmond SR. Body composition and hormonal adaptations associated with forskolin consumption in overweight and obese men. Obes Res. 2005;13:1335–1343.
Kar A, Panda S, Bharti S. Relative efficacy of three medicinal plant extracts in the alteration of thyroid hormone concentrations in male mice. J Ethnopharmacol. 2002 Jul;81(2):281-5.
Kirsten D. The thyroid gland: physiology and pathophysiology. Neonatal Netw. 2000 Dec;19(8):11-26.
Q: Can Thyro Support be used for hyperthyroidism?
A: Thyro Support stimulates the thyroid, so it is primarily for hypothyroidism, not hyper. L-Carnitine has a couple of studies suggesting that it could help with hyperthyroidism.
Q: What is the difference between iodine and iodide? Do they work differently?
A: Iodine is when the ion is free, unattached to any other element. Iodide is the term used when iodine is attached to another element (creating a salt), like Potassium iodide. There is no distinction between their mechanisms of action. In both cases it is the iodine that is the active ion.
Q: What side effects can be experienced when taking Thyro Support?
A: Thyro Support stimulates the thyroid gland. The thyroid is the principle gland in metabolism. Thus stimulation of the gland will increase all physiological effects associated with the thyroid gland. This can include heart palpitation, increased sweating, tremor of the hands, possibly transient increase in blood pressure, all symptoms similar to hot flashes. This would usually require a higher dose, however.
Body composition and hormonal adaptations associated with forskolin consumption in overweight and obese men. Obes Res. 2005;13:1335–1343.
Michael P. Godard, Brad A. Johnson, and Scott R. Richmond
Objective: This study examined the effect of forskolin on body composition, testosterone, metabolic rate, and blood pressure in overweight and obese (BMI 26 kg/m2) men. Research Methods and Procedure: Thirty subjects (forskolin, n = 15; placebo, n= 15) were studied in a randomized, double-blind, placebo-controlled study for 12 weeks.
Results: Forskolin was shown to elicit favorable changes in body composition by significantly decreasing body fat percentage (BF%) and fat mass (FM) as determined by DXA compared with the placebo group (p 0.05). Additionally, forskolin administration resulted in a change in bone mass for the 12-week trial compared with the placebo group (p 0.05). There was a trend toward a significant increase for lean body mass in the forskolin group compared with the placebo group (p=0.097). Serum free testosterone levels were significantly increased in the forskolin group compared with the placebo group (p 0.05). The actual change in serum total testosterone concentration was not significantly different among groups, but it increased 16.77 33.77% in the forskolin group compared with a decrease of 1.08 18.35% in the placebo group.
Discussion: Oral ingestion of forskolin (250 mg of 10% forskolin extract twice a day) for a 12-week period was shown to favorably alter body composition while concurrently increasing bone mass and serum free testosterone levels in overweight and obese men. The results indicate that forskolin is a possible therapeutic agent for the management and treatment of obesity.
Relative efficacy of three medicinal plant extracts in the alteration of thyroid hormone concentrations in male mice.
J Ethnopharmacol. 2002 Jul;81(2):281-5.
Kar A, Panda S, Bharti S.
Relative importance of Bacopa monnieri (200 mg/kg), Aegle marmelos (1.00 g/kg) and Aloe vera (125 mg/kg) leaf extracts in the regulation of thyroid hormone concentrations in male mice was investigated. While serum levels of both T(3) and T(4) were inhibited by A. vera, A. marmelos extract could decrease only T(3) concentration. On the other hand, T(4) concentration was increased by B. monnieri extract suggesting its thyroid-stimulating role. When the relative potency of each plant extract was calculated in terms of percent increase or decrease in thyroid hormones, as compared to the control value, the decrease in T(3) concentration by A. marmelos was about 62% indicating its possible use in the regulation of hyperthyroidism. B. monnieri could increase T(4) concentration by 41% without enhancing hepatic lipid peroxidation (LPO) suggesting that it can be used as a thyroid-stimulating drug. In fact, hepatic LPO was decreased and superoxide dismutase (SOD) and catalase (CAT) activities were increased by B. monnieri and A. marmelos leaf extracts showing their antiperoxidative role. It is thus suggested that A. marmelos and A. vera may be used in the regulation of hyperthyroidism, while B. monnieri in hypothyroidism.
The thyroid gland: physiology and pathophysiology.
Neonatal Netw. 2000 Dec;19(8):11-26.
The thyroid gland contains many follicular cells that store the thyroid hormones within the thyroglobulin molecule until they are needed by the body. The thyroid hormones, often referred to as the major metabolic hormones, affect virtually every cell in the body. Synthesis and secretion of the thyroid hormones depend on the presence of iodine and tyrosine as well as maturation of the hypothalamic-pituitary-thyroid system. Interruption of this development, as occurs with premature delivery, results in inadequate production of thyroid-stimulating hormone and thyroxine, leading to a variety of physiologic conditions. Pathologic conditions occur in the presence of insufficient thyroid production or a defect in the thyroid gland. Laboratory tests are important in diagnosing conditions of the thyroid gland. A thorough history in combination with clinical manifestations and radiologic findings are also useful in diagnosing specific thyroid conditions. Nurses play an important role in identifying and managing thyroid disorders and in providing supportive care to infants and their families.
Arthur JR, Beckett GJ.
Br Med Bull. 1999;55(3):658-68.
Normal thyroid status is dependent on the presence of many trace elements for both the synthesis and metabolism of thyroid hormones. Iodine is most important as a component of the hormones, thyroxine and 3,3′,5-tri-iodothyronine (T3) and iodine deficiency may affect approximately one billion people throughout the world. Selenium is essential for normal thyroid hormone metabolism being involved with selenium-containing iodothyronine de-iodinases that control the synthesis and degradation of the biologically active thyroid hormone, T3. Additionally, selenoperoxidases and thioredoxin reductase protect the thyroid gland from peroxides produced during the synthesis of hormones. The roles of iron, zinc and copper in the thyroid are less well defined but sub- or supraoptimal dietary intakes of all these elements can adversely affect thyroid hormone metabolism.
Forskolin stimulation of naphthylamidase in guinea pig thyroid sections detected with a cytochemical bioassay.
Acta Endocrinol (Copenh). 1985 Mar;108(3):367-71.
Ealey PA, Kohn LD, Marshall NJ, Ekins RP.
Forskolin, from the roots of the Indian medicinal plant Coleus forskohlii, has recently been shown to be a potent stimulator of adenylate cyclase in many systems, including endocrine tissues such as the thyroid gland. We describe forskolin activation of beta-naphthylamidase activity in guinea pig thyroid tissue using the cytochemical bioassay (CBA) for thyroid stimulators. This CBA is the most sensitive bioassay for TSH and LATS-B currently available, being able to detect stimulation by doses as low as 10(-5) mU TSH/l and 10(-9) mU LATS-B/l. The dose-response curve to forskolin was bell-shaped (as is seen with TSH and LATS-B) with the ascending limb of the curve produced by 10(-13) M to 10(-12) M forskolin after a 3 min exposure time. Maximal stimulation was observed with 10(-12) M forskolin. However, the dose-response curve to forskolin was not parallel to that given by TSH, the slope of the ascending limb being much greater. It has been suggested that stimulation of beta-naphthylamidase activity in the CBA is via cAMP. We report that dibutyryl cAMP at doses from 10(-16) M to 10(-11) M produces a bell-shaped dose-response curve with a very broad peak response, again not parallel to that produced by TSH. Forskolin activation of beta-naphthylamidase in the CBA is unaffected by a 1:10(6) dilution of 11E8, a monoclonal antibody raised against solubilised TSH receptors, which binds to the TSH receptor and inhibits TSH stimulation. Although the precise location of forskolin action is not known, this is further evidence that forskolin acts at a post-surface receptor site.